钩藤对吗啡诱导的大鼠条件性位置偏爱效应的影响  

Effect of Uncariae Ramulus Cum Uncis on Conditioned Place Preference Induced by Morphine in Rats

作　　者：王煜[1] 王景霞[2] 欧丽娜[2] 李伟[2] 

机构地区：[1]中国人民解放军61716部队门诊部 [2]北京中医药大学

出　　处：《中国实验方剂学杂志》2011年第14期218-220,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察钩藤提取液对吗啡诱导的大鼠条件性位置偏爱效应的影响。方法:SD雄性大鼠,取经过基线测定合格的40只大鼠,随机分为空白对照组、吗啡模型组(15 mg.kg-1,sc)、钩藤提取液低剂量(3 g.kg-1,ig)+吗啡组、钩藤提取液高剂量(9 g.kg-1,ig)+吗啡组,每组10只动物,给药5 d。采用倾向性程序训练大鼠,建立位置偏爱模型,观察钩藤提取液对大鼠在伴药箱(白箱)逗留时间的影响。结果:吗啡模型组训练5 d后,大鼠在白箱的逗留时间明显延长(与空白对照组比较,P<0.01),说明经过5 d训练,大鼠对吗啡形成了位置偏爱。给予钩藤提取液高剂量组(9 g.kg-1)能显著缩短大鼠在白箱的逗留时间(与模型组比较,P<0.05)。结论:钩藤提取液能够抑制吗啡诱导的条件性位置偏爱效应的形成,具有一定的抗药物精神依赖作用。Objective：To observe the effects of Uncariae Ramulus Cum Uncis on the conditioned place preference（CPP） induced by morphine in rats.Method： Conditioned place preference was established by morphine sc 15 mg·kg-1·d-1 for 5 d.In the training time,two Uncariae Ramulus Cum Uncis groups（3,9 g·kg-1,ig） were given Ramulus Uncariae cum Uncis after sc morphine 12 h later daily.The duration of staying in the White Compartment was recorded.Result： The 3 g·kg-1 group could not influence morphine-dependent CPP;the 9 g·kg-1 group could extinct to some extent morphine-dependent CPP.Conclusion： The result suggest that Uncariae Ramulus Cum Uncis could extinct to some extent morphine-dependent CPP and has the function of resisting psychological dependence.

关 键 词：大鼠 吗啡依赖 钩藤 条件性位置偏爱 

分 类 号：R285.5[医药卫生—中药学]