下消清和四法治疗慢性肝内胆汁淤积性黄疸  

Clinical Effect of Purgation Dispersion Purification Harmonization on Icterus Due to Chronic Cholestasis

作　　者：潘国辉 梁世香 谢和平[2] 杨宏志[2] 

机构地区：[1]广东省阳江市中西医结合医院消化内科,广东阳江529500 [2]中山大学附属第三医院中医科,广州510630

出　　处：《中国实验方剂学杂志》2011年第14期247-250,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省中医药局立项科研课题(2008065)

摘　　要：目的:观察下清消和四法治疗慢性肝内胆汁淤积性黄疸的临床疗效和安全性。方法:采用随机、对照研究方法,将慢性肝内胆汁淤积性黄疸患者85例,随机分为治疗组与对照组,治疗组43例在应用自拟下消清和四法中医药辨证组方的基础上联合常用西药对症支持治疗,对照组42例采用单纯西药对症支持治疗。结果:治疗4周后,治疗组总有效率为90.70%,明显高于对照组的83.33%(P<0.05);治疗组总胆红素(TBIL)、丙氨酸转氨酶(ALT)及谷氨酰转肽酶(γ-GT)分别下降为(52.0±20.2)μmol.L-1,(59.6±77.2),(101.8±25.9)U.L-1,与对照组比较差异具有统计学意义(P<0.05或P<0.01)。下清消和四法更能有效地促进"残黄期"黄疸的消退,且不良反应轻微,随访3个月,总胆红素与相关指标未出现反弹。结论:下消清和四法中医药辨证组方的基础上联合常用西药治疗慢性肝内胆汁淤积性黄疸疗效确切,且安全性好。Objective：To observe the clinical curative effect and safety of icterus due to divided into two groups,the treatment group（n=43） treated with the combination chronic cholestasis treated withpurgation dispersion purification harmonization.Method：Eightg-five patients with Icterus due to chronic cholestasis were selected.They were randomly of purgation dispersion purification harmonization and western medicine,the control group（n=42） with western medicine.Result： After four weeks treatment,the treatment group was superior to the control group with regard to total effective rate（90.70% vs 83.33%,P0.05） and improvement of liver function including TBIL,ALT and γ-GT（P0.05 or P0.01）.The treatment of purgation dispersion purification harmonization was effective in cleaning up remnant icterus andwithout significant side effects.After three months follow-up,the level of Tbil,ALT and γ-GT did not rebounded.Conclusion： It was effective of Using the combination of purgation dispersion purification harmonization and western medicine to treat icterus due to chronic cholestasis.This therapy could help to clean up remnant icterus and was safe.

关 键 词：胆汁淤积 黄疸 下消清和四法 中西医结合 

分 类 号：R287[医药卫生—中药学]