栀子对心脑血管系统的作用研究  

Effect of Gardeniae Fructus on Cardiovascular System

作　　者：张海燕[1,2] 邬伟魁[1] 杨军宣[3] 贺娅[1] 宋伟[1] 芦乾[1] 杨明[1,3] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [2]西南交通大学材料先进技术教育部重点实验室,成都610003 [3]成都中医药大学,成都611137

出　　处：《中国实验方剂学杂志》2011年第14期294-298,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制重大专项(2009ZX09103-393);中药新型给药系统技术平台"十一五"重大新药创制项目(2009ZX09310-005);中医药行业科研专项项目(200708006)

摘　　要：对栀子的心脑血管系统作用方面的研究进行文献整理和分析。栀子及其主要有效成分(栀子苷、京尼平、西红花酸、西红花苷等)为近年的国内外研究热点之一。研究表明,栀子在心脑血管系统方面有多种药理功效,如抗氧化、清除自由基作用,抑制血小板聚集,调节血脂,防止动脉粥样硬化等。作者主要从抗氧化、抗炎、抑制平滑肌增生、内皮细胞保护、抗凝作用等方面进行探讨。基于目前研究方法的不足,认为有必要考虑微环境对体外细胞培养的影响,今后可引入细胞联合培养技术深入研究,并注重综合运用体内外评价方法,使研究结果更加客观。并对未来研究进行了展望,以期为栀子的心脑血管疾病新药开发和临床治疗提供有益参考。Due to its multifunctional properties,it generated much attention in both the communities of research and application.To review the progress on effect of gardeniae Fructus（geniposide,genipin,crocin,crocetin） on cardiovascular system,so as to provide more information on gardeniae Fructus for further research and application.The literatures published home and abroad in recent years were consulted and summarized.Modern studies show that gardeniae Fructus not only have protective effects on endothelial cells,antioxygen,anti-inflammatory,anticoagulation and other effects,but also have protective effects against smooth muscle cells proliferation.Currently there are more studies about gardeniae Fructus iridoid glycosides against ischemic injury,and the mechanism is multifaceted.More studies are needed on the mechanism of gardeniae Fructus for treatment of cardiovascular system injury.This review expects to provide reference for preventing atherosclerosis and developing new drugs.

关 键 词：栀子 栀子苷 心脑血管 抗炎 血管细胞 

分 类 号：R285[医药卫生—中药学]