苹果酸舒尼替尼脂质体药物含量及包封率的测定  

Determination of content and entrapment efficiency of sunitinib malate liposome

作　　者：张艳晶[1] 杨强[1] 马艳铃[1] 张小飞[2] 邓意辉[1] 

机构地区：[1]沈阳药科大学,沈阳110016 [2]陕西中医学院,西安712000

出　　处：《药物分析杂志》2011年第7期1209-1212,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立苹果酸舒尼替尼脂质体含量及包封率的测定方法。方法:采用可见分光光度法测定苹果酸舒尼替尼的含量。阳离子交换树脂法分离游离药物,分光光度法测定脂质体中苹果酸舒尼替尼的包封率。结果:苹果酸舒尼替尼在430 nm处有最大吸收,4.0～15.0μg.mL-1范围内线性关系良好(r=0.9998,n=7);苹果酸舒尼替尼脂质体的平均包封率为91.89%。结论:所用方法简便、准确,可用于苹果酸舒尼替尼脂质体的含量及包封率测定。Objective：To develop a method for the determination of content and entrapment efficiency of sunitinib malate（SU）loaded liposome.Methods：The determination of SU was performed by VIS;The entrapment efficiciency of SU liposomes was determined by VIS after separation of free SU from liposome with ion exchange ions.Results：The solution of SU was absorbed max at 430 nm wavelength.The linear range of SU was 4.0-15.0 μg·mL-1（r=0.9998,n=7）.The average entrapment efficiency of SU liposomes was 91.89%.Conclusion：The method is acuurate and can be used to determine the content and entrapment efficience of SU loaded liposome.

关 键 词：苹果酸舒尼替尼 脂质体 可见分光光度法 阳离子交换树脂 游离药物 含量 包封率 

分 类 号：R917[医药卫生—药物分析学]