气相色谱法同时测定木糖醇氯化钠注射液中4种多元醇的含量  

GC simultaneous determination of four components in xylitol and sodium chloride injection

作　　者：张轶华[1] 姜建国[1] 韩学静[1] 张毅[1] 王春霞[1] 

机构地区：[1]河北省药品检验所,石家庄050011

出　　处：《药物分析杂志》2011年第7期1341-1344,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立测定木糖醇氯化钠注射液中4种多元醇(L-阿拉伯糖醇,甘露醇,半乳糖醇,山梨醇)的气相色谱(GC)法。方法:以赤藻糖醇为内标,采用毛细管气相色谱法对木糖醇氯化钠注射液中4种多元醇进行含量测定。结果:L-阿拉伯糖醇,甘露醇,半乳糖醇和山梨醇在各自的浓度范围内均具有良好的线性关系(r均为0.999以上);平均回收率(n=9)分别为98.9%～100.5%,101.0%～101.6%,99.0%～102.1%和100.9%～102.4%。结论:本方法简单、结果准确、重现性好,可更好的控制药品质量。Objective：To develop a GC method for simultaneous determination of L-arabinitol,galactitol,mannitol and sorbitol in xylitol and sodium chloride injection.Methods：GC method was applied for determination of four components and using erythritol as the internal standard.Results：There was a good linear relationship in the concentration range measured for L-arabinitol,galactitol,mannitol and sorbitol;The average recoveries（n=9） of L-arabinitol,galactitol,mannitol and sorbitol were 98.9%-100.5%,101.0%-101.6%,99.0%-102.1%和100.9%-102.4%,respectively.Conclusion：The method was simple,accurate and reproducible.It was better for quality control of xylitol and sodium chloride injection.

关 键 词：气相色谱 L-阿拉伯糖醇 甘露醇 半乳糖醇 山梨醇 赤藻糖醇 木糖醇氯化钠 注射液 

分 类 号：R917[医药卫生—药物分析学]