高血压病患者血浆内皮素及一氧化氮测定的临床意义  

Clinical significant of plasma endothelin and sera nitric oxide detection in patients with hypertension

作　　者：段巧建[1] 高世明[1] 刘镜泉[1] 罗畅民[2] 

机构地区：[1]安徽医科大学附属医院急诊科,合肥230022 [2]安徽医科大学病理生理教研室

出　　处：《中国急救医学》1999年第11期659-660,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　为探讨内皮素和一氧化氮在高血压发病中的临床意义。方法　用放免法和比色法同时测定４７ 例高血压病患者血浆内皮素和血清一氧化氮的浓度。结果　高血压病患者血浆内皮素明显高于正常组，病情越重升高越明显；血清一氧化氮则明显低于正常组，病情越重降低越明显；血浆内皮素浓度与血清一氧化氮呈显著负相关。结论　血浆内皮素和血清一氧化氮均参与高血压病的发生与发展，并与病情相关，检测内皮素和一氧化氮对判断高血压病情、估计其预后有一定参考价值。Objective To evaluate the clinical significance of plasma endothelin (ET)and sera nitric oxide (NO) detection in patients with hypertension .Methods The level of plasma ET and sera NO in 47 cases hypertension patients were measured by RIA and colorimeteric method ,respectively .Results The level of ET in the patients was much higher (123.6±14 6pg/ml)than that of the control group(87.3±12.6pg/ml),and the level of NO was much lower (4.85±0.75umol/L)than that of the control group (5.76±0.64umol/L).The changes were correlated to the severity of the diseases .Conclusions These results suggest that plasma ET and sera NO may play a part in pathophysiologic process in hypertension ,and they might served as one of indexes to assess the severity of hypertension . [

关 键 词：内皮素 一氧化氮 高血压 血浆 

分 类 号：R544.102[医药卫生—心血管疾病]