P15蛋白在尖锐湿疣组织中的表达及意义  

Expression and Significance of P15 Protein in Condyloma Acuminatum

作　　者：解春桃[1] 匡薇薇[1] 张瑞丽[1] 任虹[1] 邵银红[1] 

机构地区：[1]江苏省连云港市第一人民医院皮肤科,222000

出　　处：《职业与健康》2011年第13期1554-1556,共3页Occupation and Health

基　　金：连云港市卫生局科研基金资助项目(项目编号:08010)

摘　　要：目的研究P15蛋白在高危型人乳头瘤病毒(HPV)16/18型感染所致的尖锐湿疣组织中的表达,探讨其在尖锐湿疣发生发展中的作用。方法对经HPV分型PCR检测试剂盒检测HPV 16/18型阳性的40例尖锐湿疣组织应用免疫组织化学方法检测P15蛋白在尖锐湿疣组织中表达水平,并以35例正常组织做对照。结果在尖锐湿疣组织中和正常对照组织中,P15蛋白阳性表达率分别为70.0%、94.3%,2组间差异有统计学意义(P<0.01)。结论 P15蛋白在尖锐湿疣组织中表达降低可能与尖锐湿疣的发生发展有关。[Objective]To investigate the expression of p15 protein in condyloma acuminatum caused by high-risk human papillomavirus（HPV） 16/18 infection,explore its role in the occurrence and development of condyloma acuminatum.[Methods]40 condyloma acuminatum cases which were positive for HPV16/18 by PCR detection kit of HPV classification were collected,the immunohistochemical method was used to detect the expression of P15 protein in condyloma acuminatum,and 35 normal specimens were regarded as the controls.[Results]The positive expression rate of P15 protein in condyloma acuminatum tissue and normal controls was 70.0% and 94.3% respectively,and the difference between two groups was significant（P0.01）[Conclusion]The low expression of P15 protein may be related to the occurrence and development of condyloma acuminatum.

关 键 词：尖锐湿疣 P15蛋白 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]