老年急性心肌梗死患者血浆游离卡尼汀水平的测定及临床意义  

The clinical significance of the plasma free carnitine level in the senile patients with acute myocardial infarction

作　　者：王咏梅[1] 殷仁富[2] 吴宗贵[2] 

机构地区：[1]中国人民解放军第85医院介入科,上海200052 [2]第二军医大学附属长征医院心内科,上海200003

出　　处：《实用临床医药杂志》2011年第11期32-34,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨老年急性心肌梗死(acute myocardial infarction,AMI)患者血浆游离卡尼汀(plasma free-carnitine,PFC)水平的变化及临床意义。方法用放射性同位素酶测定法测定50例AMI患者的PFC水平,并与50例冠状动脉造影正常的对照者作比较。结果 AMI患者入院时的PFC水平为(96.24±98.33)μmol/L,高于对照组(52.94±14.12)μmol/L(P<0.05)。2周后AMI患者PFC水平下降至(62.13±31.52)μmol/L,与入院时相比差异有统计学意义(P<0.05),而与对照组相比差异无统计学意义(P>0.05),且其中有16%(8/50例)的患者PFC水平低于40μmol/L。结论患AMI后PFC水平可呈现一过性升高,随之下降,有部分患者PFC水平低于正常。提示患AMI后可能因细胞坏死导致细胞内卡尼汀释放入血而使PFC水平升高,随后恢复正常。但也有部分患者心肌梗死后可能存在体内卡尼汀缺乏,为卡尼汀治疗AMI提供临床依据。Objective To investigate the change of plasma free carnitine level（PFC） in senile patients with acute myocardial infarction（AMI）.Methods M PFC was measured with radiochemical enzymatic assay in 50 senile patients with AMI and 50 controls.Results It was observed that PFC level was increased significantly to（96.24±98.33） μmol/L after onset of AMI compared to the controls [（52.94±14.12） μmol/L,P0.05].But the PFC level was decreased to[（62.13±31.52） μmol/L,P0.05] after 2 weeks,and 16% of the patients were with a low PFC level under 40μmol/L.Conclusion The result of this study suggests that AMI may induce cardiac carnitine release and carnitine deficiency in cardiac tissue.It is suggested that supplement of L-carnitine maybe useful for the patients with AMI.

关 键 词：急性心肌梗死 左-卡尼汀 

分 类 号：R542.2[医药卫生—心血管疾病]