利奈唑胺与万古霉素治疗耐甲氧西林金葡菌所致留置导尿感染的疗效比较  

Comparison of Linezolid vs.Vancomycin in the Treatment of Retention Catheterization Infection Induced by MRSA

作　　者：卢立军 李云 

机构地区：[1]南阳医专第一附属医院,南阳市473058

出　　处：《中国药房》2011年第28期2649-2650,共2页China Pharmacy

摘　　要：目的:比较利奈唑胺与万古霉素治疗耐甲氧西林金葡菌所致留置导尿感染的疗效。方法:将病原学确诊为耐甲氧西林金葡菌感染的患者53例,随机分为利奈唑胺组(27例)和万古霉素组(26例)。利奈唑胺组给予利奈唑胺600 mg,q12h;万古霉素组给予万古霉素1 g,q12h。治疗14 d后,比较2组药物清除病原体的效果。结果:治疗14 d后,利奈唑胺组临床治愈率为66.7%,万古霉素组为23.1%,2组比较差异有统计学意义(P<0.05)。结论:利奈唑胺在治疗革兰阳性菌感染的有效性与万古霉素相当,但利奈唑胺14 d治愈率明显高于万古霉素。OBJECTIVE： To analyze the effectiveness of linezolid vs. vancomycin in the treatment of retention catheterization infection induced by methicillin-resistant staphylococcus aureus （MRSA） infections. METHODS： 53 patients with MRSA infection treated divided into linezolid group （27 cases） and vancomycin group （26 cases）. Linezolid group was given linezolid 600 mg ev- ery 12 hours, and vancomycin group was given vancomycin 1 g every 12 hours. After 14 days treatment, microbiologic eradica- tions of 2 groups of drugs were analyzed. RESULTS： After 14 days treatment, the cure rates of linezolid group and vancomycin group were 66.7% and 23.1%. There was statistical significance （P〈0.05）. CONCLUSION： The effectiveness of linezolid are sim- ilar to those of vancomycin in the treatment of gram-positive bacterial infection, but the cure rate of linezolid is higher than vancomycin in 14 days.

关 键 词：利奈唑胺 万古霉素 耐甲氧西林金葡菌 感染 

分 类 号：R978.1[医药卫生—药品]