应用蛋白质组学研究指导疾病诊断和临床用药  

Clinical diagnosis and treatment guided by proteomics

作　　者：李一石[1] 

机构地区：[1]中国医学科学院北京协和医学院阜外心血管病医院卫生部心血管药物临床研究重点实验室,北京100037

出　　处：《中国新药杂志》2011年第13期1179-1182,1187,共5页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项<创新药物临床研究技术平台建设>(2008ZX09312-018)

摘　　要：蛋白质组学技术迅猛发展,已成为当今生命科学领域中极其活跃的学科。目前,蛋白质组学研究在疾病的诊断方面得到了广泛的运用。通过比较疾病组织或血浆与正常对照之间蛋白质组的表达差异,发现与疾病发生发展相关、特异的新的蛋白标记物,促进疾病早期诊断,这在肿瘤、神经系统等疾病诊断中已经取得了一些进展。同时,尿液、唾液、脑脊液等蛋白质组学研究也相继开展,成为血浆蛋白质组学的有益补充。这些蛋白质不仅可以用来对疾病进行诊断,有的还可以在临床用药方面作为监测指标,以指导个体化用药。文中对近年来蛋白质组学在疾病诊断及其临床用药指导方面作一简要综述。With the rapid development of proteomics technologies,it has become extremely active in the field of life sciences disciplines.At present,proteomics in the diagnosis of disease has been widely used.By comparing the differential expression proteomics between the disease and normal tissues or plasma,the disease-related and specifically new protein markers were discovered and promoted early diagnosis.These have made some progress in the diagnosis of the tumor,neurological diseases and etc.Meanwhile,studies of urine,saliva,cerebrospinal fluid and other proteomics have been carried out,and become a useful complement to plasma proteomics.These proteins can be used not only to diagnose disease,and some can also provide monitoring indicators of clinical medicine to guide individual therapy.In this paper,we reviewed the recent proteomics in disease diagnosis and clinical treatment guidance.

关 键 词：蛋白质组学 疾病诊断 临床用药 

分 类 号：R969[医药卫生—药理学]