蓝萼甲素-羟丙基-β-环糊精包合物的制备  

Preparation of glaucocalyxin A-hydroxypropy-β-cyclodextrin inclusion complex

作　　者：尚校军[1] 马素英[1] 吴静[2] 白素平[1] 

机构地区：[1]新乡医学院药学院,新乡453003 [2]河南第一荣康医院,新乡453003

出　　处：《中国新药杂志》2011年第13期1243-1246,共4页Chinese Journal of New Drugs

基　　金：河南省科技创新杰出青年基金(104100510016)

摘　　要：目的:制备蓝萼甲素-羟丙基-β-环糊精包合物,提高药物体外溶解性能。方法:以羟丙基-β-环糊精为包合材料,制备蓝萼甲素包合物。使用差示热分析法对包合物进行鉴定,紫外分光光度法进行含量测定,并进行相溶解度、溶解度、体外溶出速率实验研究。结果:蓝萼甲素经羟丙基-β-环糊精包合后,溶解度、体外溶出速率均有显著提高。结论:用羟丙基-β-环糊精制备蓝萼甲素包合物,能显著改善蓝萼甲素体外溶解性能。Objective：To prepare glaucocalyxin A-hydroxypropy-β-cyclodextrin（glaucocalyxin A-HP-β-CD） inclusion complex for improving solubility and in vitro dissolution rate of glaucocalyxin A.Methods：The glaucocalyxin A-HP-β-CD inclusion complex was prepared using HP-β-CD as the carrier,and identified by differential thermal analysis（DTA）.UV-spectrophotometry was used to determine the contents of glaucocalyxin A.The phase solubility,solubility and in vitro dissolution rate were determined.Results：The solubility and in vitro dissolution rate of glaucocalyxin A were enhanced in the inclusion complex.Conclusion：Glaucocalyxin A inclusion complex prepared with HP-β-CD can remarkably increase the solubility and in vitro dissolution rate of glaucocalyxin A.

关 键 词：蓝萼甲素 羟丙基-Β-环糊精 包合物 增溶 

分 类 号：R943.4[医药卫生—药剂学]