替考拉宁联合关节镜清理和关节腔灌洗治疗膝关节感染的疗效观察  

Study on effects of teicoplanin with arthroscopic debridement and continuous lavage on treatment of knee infection

作　　者：魏民[1] 王琪[1] 李众利[1] 王志刚[1] 刘玉杰[1] 

机构地区：[1]解放军总医院骨科,北京100853

出　　处：《中华医院感染学杂志》2011年第14期3026-3028,共3页Chinese Journal of Nosocomiology

摘　　要：目的探究替考拉宁联合关节镜清理、关节腔灌洗治疗革兰阳性菌所致膝关节感染的疗效。方法 2007年9月-2010年6月静脉应用替考拉宁联合关节镜清理、关节腔灌洗治疗28例患者革兰阳性菌所致的膝关节感染,观察其药物治疗过程中的不良反应,评价临床疗效。结果治疗期间未发现药物不良反应和其他与药物有关的不良反应记录,治疗有效率为100.0%;患者均获得随访,时间4～37个月,随访期间28例患者无复发感染症状。结论替考拉宁联合关节镜清理、关节腔灌洗是治疗革兰阳性菌所致膝关节感染的有效方法。OBJECTIVE To observe the therapeutic effects of intravenous teicoplanin with debridement under arthroscopy and continuous lavage on treatment of knee infection. METHODS A total of 28 patients with knee infection were treated with intravenous teicoplanin with arthroscopic debridement and continuous lavage. All the bacteria（Methicillin-resistant Staphylococcus aureus （MRSA） in 8 knees, meticillin-resistant Staphylococcus epidermidis （MRSE） in 8 knees, coagulase-negative staphylococci（CNS） in 5 knees, enterococcus in 7 knees） were drug-sensitive to teicoplanin in drug sensitive test. The side-effect of drug were recorded during treatment. The therapeutic effects were evaluated after treatment. RESULTS During the treatment no side-effect of the teicoplanin was recorded. The effective rate of the treatment with teicoplanin with arthroscopic debridement and continuous lavage was 100%. All the patients were followed-up after treatment. The mean follow-up period was 21.5 months （range, 4 to 37 months）. During the follow-up period no patient had a recurrence o{ knee injection. CONCLUSION Intravenous teicoplanin with arthroscopic debridement and continuous lavage are effective in the treatment of knee infection.

关 键 词：替考拉宁 关节镜 灌洗 膝关节 感染 

分 类 号：R978.1[医药卫生—药品]