治痔胶囊与槐角丸体外抑菌活性比较  

Comparation of the Bacteriostasis in Vitro Between Zhizhi Capsules and Huaijiao Pills

作　　者：吴峰 曾莹[2] 梁华敏[3] 

机构地区：[1]武汉医药卫生学会联合办公室<中国医院药学杂志>编辑部,430014 [2]华中科技大学同济医学院附属协和医院药剂科,武汉430022 [3]华中科技大学同济医学院生理系,武汉430030

出　　处：《医药导报》2011年第7期870-872,共3页Herald of Medicine

基　　金：湖北省自然科学基金资助项目(基金编号:2009cdb392)

摘　　要：目的比较治痔胶囊与槐角丸的体外抑菌活性。方法采用琼脂稀释法,观察治痔胶囊与槐角丸溶液对6种常见细菌生长的抑制作用。结果治痔胶囊对常见的6种细菌均有抑菌作用,对金黄色葡萄球菌、变形杆菌、乙型链球菌的最低抑制浓度(minimal inhibitory concentration,MIC)为0.062 5 g.mL-1,对铜绿假单胞菌的MIC为0.125 g.mL-1,对大肠埃希菌的MIC为0.25 g.mL-1,对肠球菌的的最低抑菌浓度为0.5 g.mL-1。槐角丸对金黄色葡萄球菌、变形杆菌的生长有抑制作用,对两者的MIC均为0.125 g.mL-1,槐角丸对另外4种细菌生长均无抑制作用。结论治痔胶囊比槐角丸具有更广的抗菌谱和更强的抑菌能力。Objective To compare the baceriostasis in vitro between zhizhi capsules and huaijiao pills. Methods The MH agar dilution method was used to explore the in vitro bacteriostasis against 6 kinds of common bacterial growth by zhizhi capsules and huaijiao pills. Results The zhizhi capsules showed antibacterial activity against all of the 6 common bacteria,in which minimal inhibitory concentration（MIC） for Staphylococcus aureus,Bacillus proteus and Group B Streptococcus was 0.062 5 g·mL-1;MIC for Pseudomonas aeruginosa was 0.125 g·mL-1;MIC for E.coli was 0.25 g·mL-1 and for Enterococcus was 0.5 g·mL-1.But huaijiao pills only showed baceriostasis against staphylococcus aureus and proteus,MIC for both was 0.125 g·mL-1. Conclusion Zhizhi capsules have broader antibacterial spectrum and stronger bacteriostasis ability than huaijiao pills.

关 键 词：治痔胶囊 槐角丸 抑菌作用 体外 

分 类 号：R285[医药卫生—中药学]