不同剂量米索前列醇用于晚期妊娠引产效果观察  

The Dose Investigation and Effect Estimation of Misoprostol Induction in Late Pregnancy Woman

作　　者：李白鸾[1] 杨卫红[1] 张云会[1] 吕群英[1] 

机构地区：[1]昆明医学院第一附属医院产科,650031

出　　处：《中华围产医学杂志》1999年第4期198-199,共2页Chinese Journal of Perinatal Medicine

摘　　要：目的　评价米索前列醇（简称米索）用于晚期妊娠引产的效果，探讨其安全有效剂量。　方法　将１２０例有引产指征的单胎头位晚期妊娠产妇随机分为米索组和催产素作为对照组各６０例。米索组分为单次口服米索１００ μｇ 及米索５０ μｇ两组，如４～６小时后未建立有效宫缩可重复用药。于用药前及用药后１２小时进行宫颈Ｂｉｓｈｏｐ 评分、胎心监护、用药至临产时间、羊水性状、新生儿Ａｐｇａｒ评分等。用药后４８小时内临产为引产成功。　结果　用药后１２小时米索组宫颈Ｂｉｓｈｏｐ 评分平均增加４．８分，明显高于对照组（１．１分）；米索组引产成功率９７％ （５８／６０），明显高于对照组的５２％ （３１／６０）。两组胎心监护异常及胎儿窘迫发生率、新生儿Ａｐｇａｒ评分、总产程及产后出血量均无显著差异（Ｐ＞０．０５）。两种剂量米索的促宫颈成熟及引产成功率无显著差异，但１００ μｇ 组有４例仅用药１次即出现宫缩过频，５０ μｇ 组无一例宫缩过频。　结论　米索前列醇为有效快速的促宫颈成熟剂，引产成功率高，使用方便。安全、有效的剂量为５０Objective To assess the induction effect and to probe the safe dose of misoprostol used in late pregnancy women. Methods Two regimens of misoprostol (100 μg, 50 μg) were given to two groups of women in late pregnancy respectively (each group=30) compared with oxytocin induction. Result After receiving misoprostol for 12 hours the Bishop marks and induction success rate were significantly higher than that in oxytocin group. (both P <0.001), whereas the abnormality rate of IHR monitor, the fetal destress, the Apgar's marks of newborn babies, the full time of labor and the postpartum hemorrhage all shows no differences amounts the misoprostol groups and the oxytocin group, ( P <0.05), and the cervix maturation degree, the successful induction rate of the two misoprostol groups also present the same result. But in 100 μg misoprostol group, there were 4 patients complain of frequent uterus contraction well in 50 μg misoprostol group, no one suffered that. Conclusion misoprostol is an effective drug in cervix maturation promoting and of a high induction, rate in late pregnancy women. 50 μg given for each time is proposed as the effective and also safe closes.

关 键 词：米索前列醇 妊娠未期 药物引产 

分 类 号：R719.31[医药卫生—妇产科学] R984[医药卫生—临床医学]