地塞米松对内毒素肺损伤绵羊血浆、肺淋巴液神经肽和皮质醇含量的影响  

Effect of dexamethasone on the level of neuropeptides and corticosterone in endotoxin-induced lung injury in sheep

作　　者：王钧[1] 孙滨[2] 刘林英[2] 王佐忠 

机构地区：[1]第一军医大学珠江医院呼吸内科,广州510282 [2]第四军医大学呼吸内科

出　　处：《中国病理生理杂志》1999年第11期1006-1008,共3页Chinese Journal of Pathophysiology

摘　　要：目的：探讨地塞米松（Ｄｅｘ） 对内毒素肺损伤的治疗机制，观察其对体内神经肽含量变化的影响。方法：制作绵羊慢性肺淋巴瘘模型，应用大肠杆菌内毒素静脉滴入导致急性肺损伤并使用大剂量Ｄｅｘ 防治，利用放免方法测定血浆、肺淋巴液神经肽含量及血浆皮质醇（ＣＳ） 含量变化。结果：内毒素致伤后血浆、肺淋巴液中血管活性肠肽（ ＶＩＰ） 和Ｐ 物质（ＳＰ） 含量及血浆ＣＳ 含量明显升高，大剂量Ｄｅｘ 可明显抑制这一变化。结论：大剂量Ｄｅｘ 对抗内毒素所致肺损伤的作用可能部分是通过调节体内神经肽及ＣＳAIM: To explore the therapeutic mechanism of dexamethasone(Dex)for acute lung injury induced by endotoxin and observe the effect of it on the level of neuropeptides in the animal body.METHODS:Inducing acute lung injury by infusing endotoxin intravenously on sheep with chronic lung lymph fistula, proventing and treating the lung injury with high-dose Dex and assaying the changed contents of the neuropeptides in plasma and lung lymph, as well as corticosterone(CS)contents in plasma by radioimmunoassay. RESULTS: The contents of vasoactive intestinal peptide(VIP)and substance P(SP) in plasma and lymph , CS in plasma increased significantly after endotoxin injection , and a high-dose Dex can reverse it. CONCLUSION: The protective function of high-dose Dex for endotoxin-induced lung injury may be partly by regulating the content of neuorpeptides and CS in the animal body.

关 键 词：内毒素 皮质醇 地塞米松 神经肽 肺损伤 ARDS 

分 类 号：R563.02[医药卫生—呼吸系统]