几丁糖预防术后肠粘连疗效观察  

Clinical Observation of the Efficacy of Chitosan for Preventing Postoperative Ankylenteron

作　　者：付忠平[1] 谭春祈[1] 杜兴[1] 

机构地区：[1]湖南省肿瘤医院外一科,湖南长沙410013

出　　处：《医学临床研究》2011年第6期1120-1121,共2页Journal of Clinical Research

摘　　要：【目的】观察几丁糖预防术后肠粘连的临床效果。【方法]243例胃肠道恶性肿瘤手术患者，随机分成治疗组和对照组。治疗组121例应用几丁糖预防术后肠粘连，对照组122例术后直接关腹。【结果】治疗组6例（4．96％）发生粘连性肠梗阻，对照组25例（20．49％）发生，差异有显著性（P＜0．05）。两组分别有8例和12例本院再手术，比较两组腹腔粘连程度，治疗重度粘连显著低于对照组（P＜0．05）。【结论】医用几丁糖能有效减轻腹腔粘连程度及预防肠粘连的发生。[Objective] To investigate the clinical efficacy of chitosan for the prevention of postoperative ankylenteron. [Methods] Totally 243 patients undergoing the surgery of gastrointestinal malignant tumor were randomly divided into chitosan group and control group. The chitosan group（ n=121） received chitosan for preventing postoperative ankylenteron, and the control group（ n=122） underwent the closure of the abdomen after surgery. [Results] Six cases in chitosan group and 25 cases in control group occurred adhesive intestinal obstruction, and there was significant difference between two groups（ P 〈0. 05）. Eight cases in chitosan group and 12 cases in control group underwent re-operation. There was significant difference in the severity of abdominal adhesion between two groups（ P〈0.05）. [Conclusion] Medical chitosan can effectively reduce the severity of abdominal adhesion and prevent the incidence of ankylenteron.

关 键 词：肠疾病/治疗 手术后并发症 粘连/预防和控制 壳多糖/类似物和衍生物 

分 类 号：R619[医药卫生—外科学]