3,3,′5,5′-四甲基联苯二羟乙基醚的新合成方法  

A new approach for the synthesis of 3,3′,5,5′-tetramethyl-di(2-hydroxyethanyoxy)-biphenyl

作　　者：张鹏云 陈卫东[2] 杨文龙[2] 李春新 刘茵 

机构地区：[1]甘肃省化工研究院,甘肃兰州730020 [2]生态环境相关高分子材料教育部重点实验室西北师范大学化学化工学院,甘肃兰州730070

出　　处：《西北师范大学学报（自然科学版）》2011年第4期61-64,80,共5页Journal of Northwest Normal University(Natural Science)

基　　金：甘肃省科技厅"科技支撑计划"资助项目(0804GKCA019)

摘　　要：以3,3′,5,5′-四甲基联苯二酚（TMBP）和2-氯乙醇为原料在水相中一步合成了3,3′,5,5′-四甲基联苯二羟乙基醚,分别用IR和1HNMR对化合物结构进行了表征,并且探讨了反应原料配比、碱用量、还原剂用量及反应温度对产率的影响.经过反复实验得出最佳工艺条件为：n（TMBP）∶n（氯乙醇）∶n（氢氧化钠）=1∶2.5∶3.5,还原剂用量为TMBP质量的5%,温度为80℃,时间为8-9 h,产率可达到75%以上.此合成方法在工业中具有很好的应用前景.3,3′,5,5′-tetramethyl-di（2-hydroxyethanyoxy）-bibenzene（TMBE）is synthesized from 3,3′,5,5′-tetramethyl-diphenol and 2-chloroethyl alcohol by one-step method in water phase.The chemical structure of the obtained compound is characterized with FT-IR and 1HNMR.The effects of the molar ratio of reactants,the amount of base,the amount of reductant and the reaction temperature on the yield of product are investigated.The optimum process is determined and is that n（TMBP）∶n（2-chloroethyl alcohol）∶n（NaOH）=1∶2.5∶3.5,the amount of reductant based on the weight of TMBP is 5%,reaction temperture and time is 80 ℃ and 8~9 h,respectively.The yield can reach to 75%.The method is very useful from the industrial point of view.

关 键 词：3 3′ 5 5′-四甲基联苯二酚 2-氯乙醇 合成 工艺研究 

分 类 号：O625.3[理学—有机化学]