雪灵芝总皂苷对胃肠平滑肌的作用  

Snow Ganoderma lucidum Saponins on the role of the gastrointestinal smooth muscle

作　　者：达娃央金[1] 李巧云[2] 李霞 杨义龙[2] 

机构地区：[1]西藏自治区人民医院药剂科,西藏拉萨850000 [2]成都中医药大学药学院,四川成都610000 [3]成都骨科医院,四川成都610000

出　　处：《中国民族民间医药》2011年第13期48-49,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:观察雪灵芝总皂苷是否具有促进小鼠肠蠕动的作用以及对家兔离体肠肌活动的影响。方法:1.肠蠕动实验:先给雪灵芝总皂苷、甲基硫酸新斯的明、蒸馏水30min后,再给予碳末。给予碳末30min后测定碳末在肠中的推进率。2.兔子离体肠肌实验:测离体兔肠肌给药前和给药后的活动情况,研究雪灵芝总皂苷对离体肠肌活动的影响。结果:雪灵芝总皂苷高、中剂量组有明显的增加肠蠕动的作用(P<0.05),对家兔离体肠肌给药后与给药前比较,张力和振幅有显著差别(P<0.05)。结论:雪灵芝总皂苷能增加小鼠肠蠕动,对离体兔肠肌有明显的收缩作用。Objective： To Observer the Snow Ganoderma lucidum Saponins whether to promote the role of peristalsis in mice and rabbits in vitro intestinal muscle activities. Methods： Experimental of Gastrointestinal peristalsis ： To Give Snow Ganoderma lueidum Saponinss, methyl sulfate neostigmine, distilled water , After 30 minutes and then given Powder of Carbon, After 30 minutes given Powder of Carbon in the determination of intestinal promote the rate. Results： Snow Ganoderma lucidum Saponins of high, medium - dose group increased significantly the role of peristalsis （ P 〈 0. 05 ）. On rabbit intestinal muscle in vitro after administration compared with the previous administration, the amplitude and tension was significant difference. Conclusion： Snow Ganoderma lucidum Saponinss in mice can increase peristalsis, and isolated rabbit intestinal muscle contraction was obvious.

关 键 词：雪灵芝总皂苷 肠蠕动 

分 类 号：R285.6[医药卫生—中药学]