C反应蛋白与2型糖尿病血管舒张功能的关系  

C-reactive protein is associated with endothelial eependent vasodilaition function in type 2 d iabetics

作　　者：宁洁[1] 唐炜立[2,3,4] 周智广[2,3,4] 冯琼[2,3,4] 刘玉华[2,3,4] 周卫东[2,3,4] 刘志文[2,3,4] 

机构地区：[1]湖南中医药大学附属湖南省第二人民医院内分泌科,410011 [2]中南大学湘雅二医院内分泌科 [3]中南大学糖尿病中心 [4]中南大学代谢内分泌研究所

出　　处：《中国现代药物应用》2011年第12期5-6,共2页Chinese Journal of Modern Drug Application

基　　金：国家十五科技攻关项目(项目编号:2001BA702B01;2001BA702B04)

摘　　要：目的探讨高敏C反应蛋白(hsCRP)与2型糖尿病(T2DM)血管舒张功能的关系。方法用免疫比浊法测定hsCRP水平,用超声检测血管内径的变化。结果 T2DM伴亚临床动脉粥样硬化(SAS)与不伴SAS组血流介导的肱动脉内径变化率均显著低于正常对照组(P<0.05);hsCRP水平与血流介导的肱动脉内径变化率成显著负相关(P<0.05)。结论血浆hsCRP水平与T2DM患者内皮依赖性血管舒张功能呈显著负相关。Objective To investigate the association of hsCRP with the endothelial dependent vasodilatation function in T2DMpatients.Methods Compared the level of hsCRP and endothelial dependent vasodilatation in T2DM patients with or without subclinical atherosclerosis（SAS）.Results It was showed significant difference of percentage of diameter change of reactive hyperemia in three groups,percentage of diameterchange of reactive hyperemia in diabetics was higher than that of control group（P〈0.05）.There were significantly negative correlation between hsCRP and percentage of diameter change of reactive hyperemia in T2DM（P 〈005）.Conclusion Our findings suggest a negative correlation between hsCRP and endothelial dependent vasolilatation function in T2DM.

关 键 词：2型糖尿病 亚临床动脉粥样硬化 高敏C反应蛋白 内皮依赖性血管舒张功能 

分 类 号：R587.1[医药卫生—内分泌]