非瓣膜性心房颤动患者血清人巨噬细胞移动抑制因子水平的变化及意义  

The Concentrations and Significance of Plasma Human Macrophage Migration Inhibitory Factor in Non-vavular Atrial Fibrillation Patients

作　　者：裴晓阳 胡雪松[1] 邝碧娟[1] 刘伟[1] 颜雯 闵敏 

机构地区：[1]深圳市第四人民医院心内科,广东深圳518033

出　　处：《中国医药指南》2011年第19期177-178,共2页Guide of China Medicine

基　　金：深圳市科技计划项目(医疗卫生类);项目编号200903206

摘　　要：目的研究非瓣膜性心房颤动患者血清人巨噬细胞移动抑制因子(MIF)的水平,探讨非瓣膜性心房颤动发生的可能机制。方法采用定量酶联免疫吸附试验(ELISA)测定50例非瓣膜性心房颤动患者(房颤组)和50例正常人(正常对照组)血清人巨噬细胞移动抑制因子的水平。结果房颤组血清人巨噬细胞移动抑制因子水平(33.18±6.07)ng/mL明显高于正常对照组(15.79±5.16)ng/mL水平(P<0.01),且血清MMP-2水平与左房直径(LAD)呈正相关。结论非瓣膜性心房颤动患者血清人巨噬细胞移动抑制因子水平升高,血清人巨噬细胞移动抑制因子可能参与房颤的发生发展。Objectives To object the plasma levels of human macrophage migration inhibitory factor in non-vavular atrial fibrillation patients.To investigate the possible mechanism of non-vavular atrial fibrillation.Methods The plasma levels of human macrophage migration inhibitory factor in 50 non-vavular atrial fibrillation patients as fibrillation group and 50 sinus people as control group were measured by ELISA.Results The level of human macrophage migration inhibitory factor in fibrilltion group was significantly higher than that in control group（33.18±6.07）ng/mL compare（15.79±5.16）ng/mL,（P0.01）.Conculsions The level of human macrophage migration inhibitory factor in non-vavular atrial fibrilltion patients is high.Human macrophage migration inhibitory factor may take part in the development of AF.

关 键 词：非瓣膜性心房颤动 血清人巨噬细胞移动抑制因子 

分 类 号：R541.7[医药卫生—心血管疾病]