2型糖尿病患者肠道菌群的研究  

Study on Intestinal Flora of Patients with Type 2 Diabetes

作　　者：黄旭东[1] 郑晓鹏[1] 郑赵利[1] 

机构地区：[1]广东省揭阳市人民医院检验科,广东揭阳522000

出　　处：《河北医学》2011年第8期1041-1043,共3页Hebei Medicine

摘　　要：目的:分析2型糖尿病患者肠道菌群与健康个体的差异,探讨2型糖尿病与肠道菌群的相关性。方法:收集30例2型糖尿病患者(10例空腹血糖>11.1mmoL/L,余20例空腹血糖<9.0mmoL/L)和20例正常人群的新鲜粪便,利用稀释平板计数法和快速细菌鉴定法对双歧杆菌、肠杆菌科细菌、拟杆菌、乳酸杆菌、肠球菌和酵母菌进行定性、定量分析检测。结果:30例2型糖尿病患者粪便中肠杆菌科细菌数量增加,双歧杆菌和拟杆菌数量下降;10例空腹血糖>11.1mmoL/L的患者相对于20例空腹血糖<9.0mmoL/L的患者此种变化更加显著,同时出现酵母菌数量的增加。结论:2型糖尿病患者肠道内存在菌群失调,且与血糖有一定的关系。Objective：To compare intestinal flora between type 2 diabetes patient and normal people,to explore the relation between intestinal flora and type 2 diabetes.Method：We collected the feces of 30 patients with type 2 diabetes（fasting blood-glucose concentration〉11.1mmoL/L,10 cases;fasting blood-glucose concentration〈9.0mmoL/L,20 cases） and 20 normal population,then a quantitative analysis on enterobacteriaceae,enterococcus,bifidobacterium,bacteroides,lactobacillus and yeast was made.Result：Enterobacteriaceae was increased while bifidobacterium,bacteroides was decreased in feces of patient,the change was more significant in the patients with fasting blood-glucose concentration〉11.1mmoL/L,at the same time,the yeast was increased in 10 cases.Conclusion：The intestinal flora is disturbed in patients with type 2 diabetes,and there is a possible relationship between flora imbalance and blood-glucose concentration.

关 键 词：2型糖尿病 肠道菌群 菌群失调 血糖 

分 类 号：R587.1[医药卫生—内分泌]