急性心肌梗死患者BNP质量浓度与QTc间期关系及其相互作用  

The Rrelationship of Plasma BNP and QTc Interval and the Interactions in Patients With Acute Myocardial Infarction

作　　者：李帅[1] 吴慧颖[1] 郝修宏[1] 马素霞[1] 李胜利[1] 白智峰[1] 

机构地区：[1]商丘市第一人民医院心内科,河南商丘476000

出　　处：《亚太传统医药》2011年第7期58-59,共2页Asia-Pacific Traditional Medicine

摘　　要：目的:分析急性心肌梗死后心力衰竭患者血浆脑钠肽(BNP)与QTc间期关系及两者共同对急性心肌梗死预后的影响。方法:选择商丘市第一人民医院急性心肌梗死患者58例,分别测定BNP值将患者分为<500pg/mL组,500～999pg/mL组,1 000～1 999pg/mL组,>2 000pg/mL组。12导同步心电图自动测算QTc间期,同时人工测量QT间期离散度,比较4组间差异。采用秩相关分析脑钠肽质量浓度与心脏左室舒张末期容积,左室射血分数值,QTc间期和QT间期离散度(QTd)的关系。结果:①随着脑钠肽质量浓度的增加,QTc间期也随之增宽,<500pg/mL组QTc间期比其他3组窄,有统计学意义(P<0.01);而QTd只显示>2 000pb/mL与<500pg/mL组有统计学差异(P<0.01)。②秩相关分析示脑钠肽质量浓度,左心室舒张末期直径与QTc间期呈直线正相关(P<0.05～0.01)。QTc间期和QTd呈直线正相关(P<0.01)。结论:急性心肌梗死患者脑钠肽质量浓度与QTc间期有很好的相关性,两者联合应用有助于急性心肌梗死患者预后危险程度分层。Objective：To assess plasma Brain natriuretic peptide（BNP）and QTc for predicting prognosis in patients with acute myocardial infarction.Methods：58 patients with acute myocardial infarction of（67±12）years old in the first hospital of Shangqiu.The plasma BNP was measured,and according to measurements,the patients were divided into 500pg/mL group（group A）,500~999pg/mL group（group B）,1 000~1 999pg/mL group（group C）,and≥2 000pg/mL（group D）,group.QTc interval was measured by computer automately from 12-lead electrocardiogram,and the QT interval dispersion（QTd）was measured manually at the same time.The results of four groups were compared.The association of plasma BNP with left ventricular end-diastoilc volume（LVDV）,left ventricular ejection fraction（EF）,QTc and QTd was analyzed by Spearman rank correlative analysis.Results：①The QTc intervals were widened with the increase in plasma BNP;QTc interval of group A was narrower than the other groups（P0.01）;the changes in QTd showed that group D was wider than the group A（P0.01）.②The regression analysis showed that the values of BNP,left ventricular end-diastoilc volume were positively related with QTc interval（P0.05~0.01）,and QTc interval was positively related with QTd（P0.01）.Conclusion：BNP has a strong correlation with QTc interval in acute myocardial infarction patients.BNP combined with QTc could better stratify the risk degrees of patients prognosis with acute myocardial infarction.

关 键 词：急性心肌梗死 脑钠肽 QTC间期 

分 类 号：R542.22[医药卫生—心血管疾病]