地高辛与中成药联用临床血清药物浓度监测  

Monitoring Serum Concentration of Digaoxin Combined with Chinese Patent Medicine

作　　者：沈源[1] 张忠华[1] 王淑云[1] 

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《南京中医药大学学报》2011年第4期322-325,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省卫生厅科研基金资助课题(P200402)

摘　　要：目的观察地高辛与中成药联用对其血清药物浓度及临床疗效的影响。方法取我院心血管内科符合充血性心衰诊断标准的住院患者30例,随机分为2组,每组15例,选择用丹参注射液与刺五加注射液分别与地高辛联用,观察2者对地高辛血清药物浓度及临床疗效的影响。结果 2种中药注射液对地高辛的血清药物浓度没有影响,无1例不良反应发生,对心功能不全的病人的临床症状如胸闷等有所改善,这2种中药注射液分别与地高辛合用于心衰的治疗,对患者的肝、肾功能无明显影响。结论地高辛与中成药联用对其血清药物浓度影响不大。OBJECTIVE To observe the serum concentration of digaoxin combined with Chinese patent medicine and their clinical effects.METHODS 30 hospitalized patients comforming to congestive heart failure were chosen to be administrated with digaoxin accompanied by Danshen Injection and Ciwujia Injection respectively to observe their effects on the serum concentration of digaoxin.RESULTS Neither of the injections exerted influence on digaoxin＇s concentration in serum or the function of liver and kidney.They both improved clinical symptoms like chest stiffness without any case of side effects.CONCLUSION There is little effect of Danshen Injection and Ciwujia Injection on digaoxin＇s concentration in serum.They,on the contrary,can improve clinical therapeutic effects,indicating a certain synergism.

关 键 词：地高辛 血清药物浓度 肌酐清除率 肾清除率 丹参注射液 刺五加注射液 心力衰竭 

分 类 号：R969.2[医药卫生—药理学]