POEMS综合征29例临床分析  

POEMS syndrome:A clinical analysis of 29 cases

作　　者：张晓飞 张映琦[3] 陈康宁[3] 史树贵[3] 范文辉[3] 胡俊[3] 

机构地区：[1]解放军107医院高干科,山东省烟台264200 [2]西南医院神经内科 [3]第三军医大学附属西南医院神经内科,重庆市400038

出　　处：《疑难病杂志》2011年第7期492-494,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的分析POEMS综合征的临床特征,加深对POEMS综合征的认识。方法回顾性分析近6年来确诊的29例POEMS综合征的临床特点,结合相关文献进行分析。结果所有病例均有周围神经病变,多伴有肝、脾和(或)淋巴结肿大、多种内分泌病变、皮肤改变、水肿及骨髓浆细胞增多。结论 POEMS综合征是一少见的多系统损害疾病,临床表现复杂多样,诊断较难。对不明原因周围神经损害的患者,特别是合并皮肤改变、肢端水肿或者内分泌及代谢异常症状时要想到该病的可能。Objective To analyze the clinical characteristics of POEMS syndrome for improving clinical understanding of this syndrome.Methods 29 cases of POEMS syndrome were reviewed retrospectively which were diagnosed in last 6 years and analyzed with the pertinent literatures.Results All patients were shown to have peripheral neuropathy,hepatomegaly, splenomegaly,lymphadenectasis,endocrinopathy,skin changes,edema and plastcytosis in bone marrow were commonly found in these patients.Conclusion It＇s a rare multisystem disease and its clinical manifestations are complicated,which made it difficult to diagnose.When encounter with patients presented with peripheral nerve damage of unknown cause,especially combined with skin changes,peripheral edema,or endocrine metabolic disorders,POEMS syndrome should be considered.

关 键 词：POEMS综合征 多发性周围神经病 M蛋白 脏器肿大 内分泌疾病 

分 类 号：R597[医药卫生—内科学]