吡格列酮治疗磺脲类及胰岛素失效的T2DM疗效的观察  

The curative effect of pioglitazone on the T2DM patients with treatment failure of the sulfonylureas and insulin

作　　者：惠翠兰[1] 张德芳[1] 李粉萍 

机构地区：[1]陕西能源职业技术学院护理系,陕西西安710613 [2]陕西中医医院,陕西咸阳710003

出　　处：《陕西能源职业技术学院学报》2011年第2期31-34,共4页

摘　　要：目的观察吡格列酮治疗磺脲类及胰岛素失效的2型糖尿病（T2DM）的疗效。方法选择磺脲类（SU）原发性或继发性失效、以及胰岛素抵抗的T2DM患者46例，在保持原降糖药不变的基础上，加用吡格列酮片30mg（2片），1次／日，12周后观察疗效。结果46例T2DM患者，加用吡格列酮后，降糖效果显著，总有效率为79％；口服糖耐量各时相均有显著下降（P〈0．001）；胰岛素各时相均明显降低（P〈0．001）；C肽释放显示120min显著降低（P〈0．001）。结论胰岛素增敏剂治疗磺脲类及胰岛素失效的T2DM患者疗效显著。Objective To investigate the effects of pioglitazone on the T2DM patients with the treatment failure of the sulfonylureas and insulin. Methods This paper choose 46 patients with primary or secondary sulfonylureas failure and insulin resistance, added dosage of pioglitazone hydrochloride tablets to 30mg （2 tablets）, once a day,remai- ning the drugs used for the patients before unchanged. The therapeutical effect was observed 12 weeks later. Re- suits The glucose-lowering effect was significant and the total effective rate was 79%. Oral glucose tolerance various phases and insulin various phases decreased significantly （ p 〈 0. 001 ） ; The C peptide release was 120min which reduced obviously （ p 〈 0.001 ）. Conclusion The insulin sensitizer have a significant curative effect on the T2DM patients with the treatment failure of sulfonylureas and the insulin.

关 键 词：吡格列酮 磺脲类及胰岛素失效 疗效 

分 类 号：R587.1[医药卫生—内分泌]