仙鹤草水提液对D-半乳糖衰老模型小鼠的影响  

The effect of Agrimoni a pilosa Ledeb on aging mice induced by D-galactose

作　　者：陆英[1] 张洁[2] 

机构地区：[1]江苏省海门市悦来医院,226131 [2]南通大学

出　　处：《齐齐哈尔医学院学报》2011年第10期1542-1543,共2页Journal of Qiqihar Medical University

摘　　要：目的观察仙鹤草水提液对D-半乳糖衰老模型小鼠的影响。方法建立D-半乳糖致小鼠衰老模型,以Y型电迷宫检测其学习记忆能力,分别采用黄嘌呤氧化酶法、TBA比色法测定大脑SOD活性和MDA含量,观察小鼠服用仙鹤草水提液后上述指标的变化。结果与D-半乳糖模型组相比,仙鹤草水提液中、高剂量可提高衰老模型小鼠的学习记忆能力(P<0.05),增加D-半乳糖所致衰老模型小鼠大脑SOD活性、降低MDA含量(P<0.05)。结论仙鹤草水提液能改善D-半乳糖所致衰老小鼠的多项体征。Objective To study the effect of Agrimoni a pilosa Ledeb on aging mice induced by D-galactose so as to provide the experimental evidence for the application of Agrimoni a pilosa Ledeb to protect and cure the neurodegeneration diseases. Methods With the model of aging mice induced by D-gal,the learning memory ability of mice was measured by using Y-maze.The contents of SOD and MDA in the cerebrums were determined by xanthine oxidation or TBA colorimetry,the variations of above indices of mice after treatment with Agrimoni a pilosa Ledeb were observed.Results In D-gal＋ Agrimoni a pilosa Ledeb（middle an d high doses）groups,the abilities of learning-memory of aging mice were remarkably improved,the activities of SOD increased and the MDA content decreasd remarkablv in the cerebrums of mice compared with D-gal model group（P0.05）.Conclusions Agrimoni a pilosa Ledeb can ameliorate aging symptoms in mice induced by D-gal.

关 键 词：仙鹤草水提液 D-半乳糖 衰老 小鼠 学习记忆 黄嘌呤氧化酶法 TBA比色法 

分 类 号：R977.9[医药卫生—药品]