白介素4受体I50V、Q576R、P761基因多态性与尘螨变应性鼻炎的关系探讨  

Correlative study on interleukin-4 receptor I50V、Q576R、P761 polymorphisms in allergic rhinitis with

作　　者：黎毓光[1] 刘志伟[1] 卢建鹏[1] 李敏雄[2] 陈盛强[2] 赖荷[2] 

机构地区：[1]广州市番禺区人民医院,广东广州511400 [2]广州医学院第二附属医院,广东广州510260

出　　处：《实验与检验医学》2011年第3期235-238,309,共5页Experimental and Laboratory Medicine

基　　金：广州市番禺区科技攻关项目(2009-z-11-1)

摘　　要：目的探讨白介素4受体I50V、Q576R、P761基因与尘螨变应性鼻炎遗传易感性的相关性。方法用PCR-RFLP法为88名无亲缘关系的尘螨变应性鼻炎患者和102名无血缘关系的健康汉族人进行白介素4受体Q576R、I50V、P761基因分型。结果尘螨变应性鼻炎组的I50V、Q576R和P761基因型频率与对照组相比,均无显著性差异(P值均大于0.05)。结论本实验结果显示I50V、Q576R和P761基因尚不能被认为是尘螨变应性鼻炎的候选易感基因。Objective To investigate the correlation of interleukin-4 receptor I50V,Q576R,P761 genes and allergic rhinitis with dust mites.Methods Interleukin-4 Receptor Q576R,I50V,P761 genes in unrelated healthy individuals of Han nationality and the cases of allergic rhinitis with dust mites were genotyped by PCR-RFLP technique.Results Interleukin-4 Receptor Q576R,I50V,P761 genes in patient group was no significant difference compared with control group（P0.05）.Conclusion Interleukin-4 Receptor I50V,Q576R,P761 are not associated with allergic rhinitis with dust mites.

关 键 词：尘螨 变应性鼻炎 白细胞介素4受体 多态性 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]