血浆microRNAs在慢性肝损伤诊断中的应用研究  

Applied research of plasma microRNA in the diagnosis of chronic liver injury

作　　者：江梅[1] 万腊根[1] 

机构地区：[1]南昌大学第一附属医院检验科,江西南昌330006

出　　处：《实验与检验医学》2011年第3期258-260,241,共4页Experimental and Laboratory Medicine

基　　金：江西省卫生厅科研项目;编号20111022

摘　　要：MicroRNAs(miRNAs)是内源性无编码功能的小分子单链RNA,长约21-23核苷酸,在许多脏器慢性损伤的发生和发展中起着重要作用。由于他们的大小、数量、组织特异性以及血浆中的相对稳定性,使得miRNA有望成为用于诊断组织损伤的分子生物学标记物。本文就血浆miRNA用于诊断慢性肝损伤的应用研究作一综述。MicroRNAs（miRNAs） is endogenous,small non-protein-coding single strand RNA molecules with 21-23 nucleotides.MiRNAs play an important role in the development and progression of chronic injury in many organs,miRNAs has been reported as promising potential molecular biology biomarkers for various injury organs as their size,quantity,tissue specificity,and relative stability in the plasma.This review summarizes on research and clinical application of microRNA in the chronic liver injury.

关 键 词：MIRNA 慢性肝损伤 分子生物学标记物 

分 类 号：Q522[生物学—生物化学]