口服坦索罗辛与硝苯地平辅助治疗肾绞痛的临床效果比较  

Comparison of clinical effecacy between tansulosoin and nifedipine on adjuvant therapy of renal colic

作　　者：王健[1] 张海滨[1] 谭兴银[1] 叶珊[1] 卢建棠[1] 

机构地区：[1]佛山市第一人民医院泌尿外科,广东佛山528000

出　　处：《岭南现代临床外科》2011年第1期59-60,共2页Lingnan Modern Clinics in Surgery

摘　　要：目的分析比较坦索罗辛与硝苯地平辅助治疗肾绞痛的临床疗效及临床耐受性。方法 500例输尿管结石致肾绞痛患者随机分为两组,A组常规止痛治疗加用坦索罗辛口服0.4mgqd;B组常规止痛治疗加用硝苯地平10mgtid。所有患者被要求饮水2L/天,疗程为4周或至结石排出。观察患者疼痛缓解情况(视觉模拟量表)、结石排出率、生活质量评分以及药物副作用发生率并作统计分析。结果 A组患者疼痛缓解情况(视觉模拟量表)、结石排出率、生活质量评分均优于B组患者(P<0.05),两组药物副作用发生率无差别。结论口服坦索罗辛辅助治疗肾绞痛总体效果优于口服硝苯地平,可以减轻患者的绞痛程度、减少止痛药的用量和辅助排石,且临床耐受性好。Objective To compare the efficacy and the tolerance of tamsulosin and nifedipine for the adjuvant therapy in patients with renal colic.Methods Five hundred patients suffered from renal colic with ureteral calculi were randomly divided into 2 groups（250 patients in each group）.Group A received routine therapy adjuncted with tamsulosin 0.4 mg q.d.and group B received routine therapy adjuncted with nifedipine 10 mg tid.The patients were asked to drink at least 2 liters water a day.Visual analog scale（VAS）,stone clearance rate,quality of life score and the incidence rate of side effects were statistically analyzed after 4 weeks or after the stone was eliminated.Results In the visual analog scale（VAS） and quality of life score,the group A was superior to group B（P0.05）.The stone clearance rate was significently increased in group A compared to in group B.The incidence rate of side effects had no differences between two groups.Conclusions Tamsulosin is more effective than nifedipine for adjuvant therapy in patients with renal colic.And it has a good clinical tolerance.

关 键 词：肾绞痛 泌尿系结石 坦索罗辛 硝苯地平 

分 类 号：R692[医药卫生—泌尿科学]