抑制体内NO的产生无法减弱清醒大鼠的过敏性低血压反应  

L-NAME CANNOT ATTENUATES ANAPHYLACTIC HYPOTENSION IN CONSCIOUS RATS

作　　者：张伟[1] 张昱[2] 

机构地区：[1]青海大学高原医学研究中心 [2]青海大学医学院生物学教研室

出　　处：《青海医学院学报》2011年第2期73-76,共4页Journal of Qinghai Medical College

摘　　要：目的观察体内NO被抑制时的清醒大鼠的过敏性低血压反应。方法应用清醒大鼠过敏性休克动物模型,利用血管插管法持续监测系统平均动脉压、心率和门静脉压。结果对照组经抗原诱导产生过敏性低血压,随着门静脉压的升高MAP降低,经抗原诱导48小时未发生死亡。经非选择性NOS抑制剂L-NAME(10 mg/kg)预处理组MAP在抗原诱导前后均明显高于对照组,而且MAP的降低量和门静脉压的升高量均明显大于对照组,结果经抗原诱导在12小时内全部发生死亡。结论在清醒状态下的大鼠体内由NOS产生的NO参与了过敏性低血压的发生,但对过敏性低血压大鼠应用非选择性NOS抑制剂却是致命的。Objective To explore the effects of nitric oxide（NO） in vivo and nonselective NOS inhibitor on the anaphylactic hypotension in conscious rats.Methods Mean arterial pressure（MAP） heart rate and portal venous pressure were directly and simultaneously measured in anaphylactic hypotension models.Results The control rats showed a decrease in MAP along with an increase in portal venous pressure,but did not die within 48 hours after antigen injection.In the rats pretreated with L-NAME（10mg/kg）,MAP before and after antigen was significantly higher than that of the control rats,but the net decrease in MAP as well as an increase in portal venous pressure was rather greater than that of the control,resulting in fatal outcome within 12 hours after antigen.Conclusion In anaphylactic hypotension of unanesthetized rats,NO derived from in vivo NOS,but inhibition of NOS is lethal.

关 键 词：一氧化氮 清醒大鼠 过敏性低血压 

分 类 号：R331.35[医药卫生—人体生理学]