Diels-Alder反应的理论研究新进展  

Progress of the Theory Study on Diels-Alder Reactions

作　　者：徐文媛[1] 杜瑞焕[1] 龙威[1] 

机构地区：[1]华东交通大学基础科学学院,江西南昌330013

出　　处：《华东交通大学学报》2011年第3期60-64,共5页Journal of East China Jiaotong University

基　　金：国家自然科学基金项目(30760137);江西省自然科学基金项目(2008GQH0060);华东交通大学研究生创新基金项目(YC10C016)

摘　　要：Diels-Alder反应已经成为合成六元环加成化合物、天然萜类化合物和药物中间体、哌啶衍生物的一个关键步骤,随着在合成领域取得令人瞩目的成果,Diels-Alder反应的机理研究也取得了一定的进展。该文综述了国内外Diels-Alder反应最新的理论研究,在催化剂lewis酸、噁唑硼烷、水溶剂、离子溶剂和超临界CO2溶剂等反应条件下,从热力学,动力学的角度总结分析了各个条件对反应速率,立体选择性的影响,并对理论的研究方向进行了展望。Diels-Alder reaction is used as a key step in synthese of six-membered cycles,terpene natural products,drug intermediates,piperidine derivatives.With the distinct achievements on the synthesis,some theoretical progresses of Diels-Alder reactions are accomplished.This paper reviews the latest theoretical researches of Diels-Alder reaction at home and abroad.Based on the theory of quantum chemistry,the effect of the catalysts（such as AlCl3 or oxazaborolidines） and solvents（such as water,ionic liquids and supercritical-CO2 fluid） are discussed.Those influences on the rate and highly stereoselective of reaction are investigated in detail.In addition,the theoretical future in Diels-Alder Reactions is forecasted,which adapts to the development of Green Chemistry.

关 键 词：DIELS-ALDER B3LYP/6-311G 噁唑硼烷 离子液体 水 超临界CO2流体 

分 类 号：O64[理学—物理化学]