钯催化反应合成噻唑类化合物  

Preparing Biaryl Compounds Containing Thiazole Rings by Pd-Catalyzed Reactions

作　　者：张罡[1] 苏箐[1] 

机构地区：[1]河南城建学院化学化工系,河南平顶山467001

出　　处：《广州化工》2011年第13期87-88,98,共3页GuangZhou Chemical Industry

摘　　要：以Pd(PPh3)4为催化剂,以2-溴噻唑和连有不同取代基团的苯硼酸为原料合成了系列芳基噻唑偶联化合物,考察了多种溶剂、不同种类碱和催化剂比例等反应条件的变化对产品收率的影响,并通过单因素法优化了芳基噻唑偶联反应的条件。同时研究了芳基硼酸上连有不同取代基时,对反应收率的影响,并总结其反应规律。A series of biaryl compounds containing thiazole rings were prepared by using Pd（PPh3）4 as catalyst through the Pd-catalyzed Suzuki cross-coupling reactions of 2-bromothiazole with different substrates of phenylboronic acid.In these reactions,several factors including the influences of bases,solvents and Pd catalysts on the reactions were investigated through single-factor approach,and the optimum reaction condition was obtained.Then the effects of different molecular structures on the reaction were discussed.

关 键 词：钯催化 SUZUKI偶联反应 2-溴噻唑 芳基硼酸 

分 类 号：TQ455[化学工程—农药化工]