1,3-丁二酮类衍生物对S-180肉瘤细胞生长抑制作用体外实验研究  

Effects of ramification of 1,3-dioxo-1-phenylbutan on the proliferation of murine S180 sarcoma cells

作　　者：严轶琛[1] 朱志博[1] 雷林生[1] 

机构地区：[1]南方医科大学药学院化学系,广东广州510515

出　　处：《西北药学杂志》2011年第4期276-278,共3页Northwest Pharmaceutical Journal

摘　　要：目的观察1,3-丁二酮类衍生物对S180肿瘤细胞生长的影响,为进一步的研究提供依据。方法细胞增殖程度采用MTT比色法。结果 1,3-丁二酮衍生物B具有较强的抑制S180细胞增殖的作用;1,3-丁二酮衍生物A对S180细胞增殖抑制作用较弱。结论 1,3-丁二酮衍生物B对小鼠S180肿瘤细胞体外增殖有明显抑制作用。Objective To study the effects of ramification of 1,3-dioxo-1-phenylbutan on the proliferation of murine S180 sarcoma cells,and to provide evidence for the further study.Methods Cell proliferation was detected by methyl thiazolyltetrazolium assay（MTT）.Results The compound B had strong inhibitory effect on the growth of murine S180 sarcoma cells,whereas the compound A showed weaker effects.Conclusion Ramification of 1,3-dioxo-1-phenylbutan has markedly inhibitory effect on the growth of mouse S180 sarcoma cells

关 键 词：1 3-丁二酮 抗肿瘤 MTT比色法 

分 类 号：R965[医药卫生—药理学]