卡维地洛对那格列奈在大鼠体内药物动力学的影响  

Effect of carvedilol on pharmacokinetics of nateglinide in rats

作　　者：刘茜[1] 邵馨[1] 赵辉[1] 褚雨[1] 刘艳芳[1] 

机构地区：[1]沈阳药科大学药物分析实验室,沈阳110016

出　　处：《中南药学》2011年第6期427-430,共4页Central South Pharmacy

摘　　要：目的研究卡维地洛对那格列奈在大鼠体内药物动力学的影响。方法 10只健康雄性Wistar大鼠随机分成2组(单独给药组和联合给药组),用HPLC-MS/MS法测定血浆中那格列奈的浓度。结果单独用药与联合用药组Cmax分别为(1 868±226.3)和(992.8±246.0)μg.L-1,AUC0-t分别为(1 532.1±526.5)和(822.5±298.0)μg.h.L-1,AUC0-∞分别为(1 546.2±530.7)和(845.1±312.0)μg.h.L-1,均具有显著性差异(P<0.05),其他药动学参数无显著性差异(P>0.05)。结论联合用药后卡维地洛抑制了那格列奈的吸收。Objective To investigate the effect of carvedilol on pharmacokinetics of nateglinide in rats.Methods Ten healthy male Wistar rats were divided into 2 groups（ig administration of nateglinide alone and combination of carvedilol and nateglinide）.The plasma concentration of nateglinide was determined by HPLC-MS/MS.Results The pharmacokinetic parameters of nateglinide in the healthy rats after ig administration of nateglinide alone and combination of carvedilol and nateglinide were as follows： Cmax was（103.0±26.6） and（72.6±9.23） g·L-1,AUC0-t was（1 532.1±526.5） and（822.5±298.0）μg·h·L-1;AUC0-∞ was（1 546.2±530.7） and（845.1±312.0） μg·h·L-1,which showed significance difference（P〈0.05）.There were no significant differences in the other pharmacokinetic parameters between the two groups（P〉0.05）.Conclusion The absorption of nateglinide is lower after combination with carvedilol.

关 键 词：卡维地洛 那格列奈 高效液相色谱-质谱联用 药物动力学 

分 类 号：R969.1[医药卫生—药理学] R927.1[医药卫生—药学]