麻黄常规粉体与超微粉体中麻黄碱在小鼠肺部药物浓度的比较研究  

Concentration of ephedrine in traditional and ultra-micro ephedra powder in the lung of mice

作　　者：罗正红[1] 邹龙[1] 桂卉[1] 颜红[1] 郭锦明[1] 李志华[1,2] 蔡光先[1] 

机构地区：[1]湖南中医药大学,长沙410208 [2]冷水江市中医院,湖南冷水江417500

出　　处：《中南药学》2011年第6期464-466,共3页Central South Pharmacy

基　　金：国家科技公关课题(2001BA701A43);湖南省科技厅科研科技计划重点项目(06Sk2005)

摘　　要：目的测定麻黄常规粉体与超微粉体中麻黄碱在小鼠肺部的浓度,探讨不同粒径麻黄粉体对麻黄碱在小鼠肺部浓度的影响。方法小鼠以相同剂量灌胃给予常规与超微2种麻黄粉体后,在规定的时间点摘取肺,匀浆处理后用HPLC法测定其中麻黄碱的含量。结果超微粉体组肺内麻黄碱含量明显高于常规粉体组。结论超微粉体可提高麻黄药物在小鼠肺内的药物浓度。Objective To study the concentration of ephedrine in ephedra traditional powder and ultra-micro powder in the lung of mice, and discuss the effect of different particle sizes of ephedra on distribution. Methods The mice were divided into 2 groups： one was given traditional powder and the other was given ultra-micro powder. The distribution of ephedrine in the lung was analysed by HPLC method. Results The ultra-micro powder distributed faster than the traditional powder, and the concentration was obviously higher than the latter. Conclusion The ultra-micro powder can increase the concentration of ephedrine in the lung of mice.

关 键 词：麻黄 麻黄碱 常规粉体 超微粉体 肺 分布 

分 类 号：R969.1[医药卫生—药理学] R927.1[医药卫生—药学]