养生方破壁粉粒的药效学观察  

Pharmacodynamics Study of Cell-wall-broken Powder of Health Preservation Recipe

作　　者：成金乐 陈健文[2] 邓雯 徐吉银 彭丽华[3] 刘培庆[2] 黄芝瑛[2] 

机构地区：[1]中山市中智药业集团有限公司,广东中山528437 [2]中山大学,广东广州510006 [3]广州中医药大学中药资源科学与工程研究开发中心,广东广州510006

出　　处：《广州中医药大学学报》2011年第4期402-405,459,460,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东粤港关键领域重点突破招标项目(编号:20080106-2);广东省科技计划项目(编号:粤科计字[2008]72号);中山市科技强企支撑计划项目(编号:20092A113)

摘　　要：【目的】观察养生方破壁粉粒保肝、增强免疫和活血的药效学作用。【方法】采用四氯化碳致小鼠急性肝损伤、血清溶血素测定以及对大鼠血液流变学的影响等指标观察养生方破壁粉粒的药效学作用,并与养生方饮片进行比较。【结果】养生方破壁粉粒中、高剂量组能抑制血清谷丙转氨酶(AST)和谷草转氨酶(ALT)的升高,改善肝脏的病理学损伤;升高血清溶血素值;降低血浆粘度和全血低、中、高切粘度,从而改善血液流变学的状态。【结论】养生方破壁粉粒具有一定的保肝、改善免疫及血液流变学状态的作用。同等给药剂量比较,养生方破壁粉粒作用优于饮片。Objective To observe the effect of cell-wall-broken powder of Health Preservation Recipe on protecting hepatic function,enhancing immunity and activating blood.Methods Carbon tetrachloride was used to induce acute liver injury in mice.Serum hemolysin and hemorheology of rats were observed to evaluate the pharmacological action of cell-wall-broken powder of Health Preservation Recipe.Then the effect was compared with that of Health Preservation Recipe in sliced herbal medicine.Results High-and middle-dosage of Health Preservation Recipe in cell-wall-broken powder obviously inhibited the increase of serum aspartate aminotransferase（AST） and alanine aminotransferase（ALT）,relieved hepatic pathological injury,and increased serum hemolysin.They also decreased plasma viscosity,and whole blood low-,middle-and high-shear viscosity,and improved hemorheology.Conclusion Cell-wall-broken powder of Health Preservation Recipe exerts certain effect on protecting hepatic function,enhancing immunity and improving hemorheology,and the effect is superior to that of Health Preservation Recipe in sliced herbal medicine.

关 键 词：养生方/药理学 破壁粉粒/治疗作用 肝/病理学 疾病模型 动物 大鼠 小鼠 

分 类 号：R285.5[医药卫生—中药学]