0.5%酮咯酸氨丁三醇眼液在飞秒激光LASIK手术中的应用与观察  

Application and Observation of 0.5% Ketorolac Tromethamine Eye Drops in the Femtosecond Laser LASIK Surgery

作　　者：石钰[1] 赵玉兰[1] 高国先 詹妮曼 李彩芳[1] 

机构地区：[1]广州爱尔眼科医院,广东广州510288

出　　处：《临床医学工程》2011年第7期1081-1082,共2页Clinical Medicine & Engineering

摘　　要：目的观察0.5%酮咯酸氨丁三醇滴眼液在飞秒激光制作角膜瓣后对眼部刺激症的抑制效果。方法采用自身对照法观察30例(60只眼)接受飞秒激光手术的患者,右眼飞秒激光制作角膜瓣后立即滴用0.5%酮咯酸氨丁三醇滴眼液为试验组,左眼飞秒激光制作角膜瓣后不滴用任何眼液为对照组。观察左、右眼在等待气泡吸收的15分钟内,眼部刺激症状的表现程度。结果两组在眼部刺激症状表现程度上有明显差异,试验组30只眼中0级无眼部刺激反应的21只眼,占本组的70%;1级轻度反应8只眼,占本组26.6%;2级中度反应1只眼,占本组3.3%;对照组30只眼中0级无眼部刺激症状的4只眼,占本组13.3%;1级轻度19只眼,占本组63.3%;2级中度7只眼,占本组23.3%。两组进行fisherexacttest,P<0.05。结论 0.5%酮咯酸氨丁三醇滴眼液属于非甾体抗炎药,可有效控制眼前节炎症消退,降低角膜敏感性,具有镇痛、消炎、抗敏感作用。通过对两组的比较分析,认为0.5%酮咯酸氨丁三醇滴眼液可有效缓解和抑制飞秒激光制作角膜瓣后的眼部刺激症状,有助于准分子激光切削时患者与医生的配合,提高手术效果,是安全和有效的。Objective To observe the inhibitory effect of eye irritation by dropping 0.5% ketorolac tromethamine eye drops after femtosecond laser surgery for making corneal flap.Methods Self-control was applied to 30 patients（60 eyes） who received laser surgery,the right eyes which were dropped 0.5% ketorolac tromethamine eye drops immediately after femtosecond laser surgery for making corneal flap were set as the test group,whereas the left eyes which were not dropped 0.5% ketorolac tromethamine eye drops after femtosecond laser surgery for making corneal flap were set as the control group.To observe the performance of eye irritation of left and right eyes while waiting for the bubble absorption within 15 minutes.Results There was significant difference between the two groups in eye irritation.In 30 eyes of the test group there were 21 eyes with no eye irritation at level 0,accounting for 70% of the group;8 eyes with minimal response at level 1,accounting for 26.6% of the group;1 eye with moderate response at level 2,accounting for 3.3% of the group;in 30 eyes of the control group 4 eyes with no eye irritation at level 0,accounting for 13.3% of the group;19 eyes with minimal response at level 1,accounting for 63.3% of the group;7 eyes with moderate response at level 2,accounting for 23.3% of the group.Fisher exact test was performed in the two groups（P 0.05）.Conclusion 0.5% ketorolac tromethamine eye drops is the non-steroidal anti-inflammatory drugs which effectively control the anterior segment inflammation subsidise,can lower corneal sensitivity and have effect of analgesic function,anti-inflammatory and anti-sensitive.Through comparative analysis of the two groups,0.5% ketorolac tromethamine eye drops is considered to effectively inhibit and mitigate the eye irritation after femtosecond laser surgery for making corneal flap,and also help patients coordinate with doctors during the femtosecond laser surgery to improve the surgical results with safety and effectiveness.

关 键 词：飞秒激光 0.5%酮咯酸氨丁三醇滴眼液 眼部刺激征 

分 类 号：R473.77[医药卫生—护理学]