红外期疟疾疫苗的研究进展(英文)  

Advances in pre-erythrocytic stage malaria vaccine

作　　者：彭小红[1] 黄复生[1] 

机构地区：[1]第三军医大学基础部病原生物学教研室,重庆400038

出　　处：《成都医学院学报》2011年第2期118-123,共6页Journal of Chengdu Medical College

基　　金：国家自然科学基金项目(No.30972570,30872366)

摘　　要：红外期是疟原虫侵入宿主的第一个时期,有效的红外期疟疾疫苗对控制疟疾的发病和流行具有重要的作用。目前研究中的红外期疟疾疫苗主要有亚单位疫苗和全虫疫苗两种,其中后者包括了放射减毒子孢子疫苗和基因减毒子孢子疫苗。全虫疫苗虽然能够诱导完全性的免疫保护作用,但是其生产及运输方式却限制了它的现场应用。目前的亚单位疫苗不能达到让人满意的保护效应,有效亚单位疫苗的研制还需要对相关的机制做进一步深入的研究。本文仅就目前这些疫苗的研究进展作一综述。Pre-erythrocytic stage is the first stage which Plasmodium to invaded a human host,effective malaria vaccine for pre-erythrocytic stage has important significance to control the morbidity and the prevalence of the malaria.The present study of malaria vaccines for pre-erythrocytic stage include subunit vaccines and whole-cell vaccines,the latter is also included irradiation-attenuated sporozoites and genetically attenuated sporozoites.Although whole-cell vaccines induce complete and long-lasting protection,the difficulties to produce and transport have limited its clinical application.The current subunit vaccines are still not achieve satisfactory protective effect,and the relevant mechanisms need further in-depth study.Here,we do a review on the development of these vaccines.

关 键 词：疟疾 红外期 疫苗 

分 类 号：R392[医药卫生—免疫学]