生长因子在大鼠前列腺组织中的表达及雄激素的调控作用  

Expression of growth factors in rat prostatic tissues—The modulation function of androgen

作　　者：许清泉[1] 朱积川[1] 姜辉[1] 王晓峰[1] 侯树坤[1] 刘庆理[2] 

机构地区：[1]北京医科大学人民医院泌尿外科,100044 [2]河北秦皇岛市第一医院泌尿外科

出　　处：《中华实验外科杂志》1999年第6期504-505,共2页Chinese Journal of Experimental Surgery

摘　　要：目的　观察雄激素水平改变对大鼠前列腺组织碱性成纤维细胞生长因子（ｂＦＧＦ） 和转化生长因子β１（ＴＧＦβ１）表达的影响。方法　采用分子杂交技术研究ｂＦＧＦｍＲＮＡ 及ＴＧＦβ１ｍＲＮＡ 在去势和未去势大鼠前列腺组织中表达的差异。结果　去势组ＴＧＦβ１ｍＲＮＡ 杂交斑点ＩＯＤ 均值为３１５．５，是未去势组（１７９）的１．７６ 倍；而未去势组ｂＦＧＦｍＲＮＡ 杂交斑点ＩＯＤ 均值为４４５ ．３，是去势组（２００．３） 的２．２２倍，差异均有显著性（Ｐ＜０ ．０１）。结论　雄激素水平变化可影响ｂＦＧＦｍＲＮＡ 及ＴＧＦβ１ｍＲＮＡ 的表达，ｂＦＧＦ及ＴＧＦβ１ 介导雄激素的作用。Objective In order to investigate the effect of androgen on the expression of growth factors in rat prostatic tissues. Methods The expression of basic fibroblast growth factor (bFGF) mRNA and transforming growth factor β1 (TGFβ1) mRNA in castration rats or normal rats were studied by using molecular hybridization method. Results The expression of TGFβ1 mRNA in castration group was 1.76 times of that in normal group, whereas the expression level of bFGFmRNA in normal group was 2.22 times of that in castration group ( P <0.01). Conclusion Androgen may influence the expression of bFGFmRNA and TGFβ1 mRNA in rat prostatic tissues. bFGF and TGFβ1 may mediate the action of androgen.

关 键 词：BFGF TGFΒ1 雄激素 前列腺增生 大鼠 

分 类 号：R697.320.2[医药卫生—泌尿科学]