维生素D与支气管哮喘研究进展  

Progress of vitamin D and bronchial asthma

作　　者：陈伟伟(综述)[1] 蔡栩栩(审校)[1] 

机构地区：[1]中国医科大学附属盛京医院小儿呼吸科,沈阳110004

出　　处：《国际儿科学杂志》2011年第4期364-367,共4页International Journal of Pediatrics

基　　金：沈阳市科学技术计划项目（1081269-9-00）

摘　　要：维生素D作为一种免疫调节剂与支气管哮喘的发生、发展关系密切。维生素D参与了胎儿肺和免疫系统的发育；流行病学调查发现，维生素D缺乏和哮喘的发病率上升及哮喘的严重程度有关；维生素D对哮喘的发生有早期干预作用，而且在糖皮质激素耐受性哮喘的治疗和特异性免疫疗法中发挥辅助作用。As an immune regulator, vitamin D plays a role in asthma. In the fetus, vitamin D participates in immune system and lung development. It has been reported that vitamin D deficiency may explain a portion of the asthma epidemic. Beneficial associations have been reported between vitamin D and asthma severity in children. Epidemiologic studies have also suggested that higher prenatal vitamin D intakes have a protective role against wheezing illnesses in young children. In addition, vitamin D may play a therapeutic role in steroid resistant asthmatics and there is interest in using vitamin D therapeutically to complement conventional asthma theraov, such＇ as soecific immunotherapy.

关 键 词：维生素D 维生素D受体 支气管哮喘 

分 类 号：R725.914.4[医药卫生—儿科]