支气管哮喘患者IL-4、sICAM-1、IFNγ与IgE的相关性研究  

Relationship between IL-4,sICAM-1,IFNγ and IgE in allergic bronchial asthma

作　　者：唐爱霞[1] 李军[2] 孟祥云[1] 安符臣 赵昆[1] 

机构地区：[1]西安市第一医院呼吸内科,710002 [2]陕西省肿瘤防治研究所基础研究室,西安710061

出　　处：《中国实用内科杂志》1999年第11期665-666,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的　探讨支气管哮喘患者血清中白介素－ ４（ＩＬ－ ４）、可溶性细胞粘附因子－１（ｓＩＣＡＭ－ １）、γ干扰素在支气管哮喘发病中的作用及与ＩｇＥ水平的相关关系。方法　分别在支气管哮喘发作期、缓解期及口服强的松治疗后用ＥＬＩＳＡ双抗体夹心法分别测定血清中ＩＬ－４、ｓＩＣＡＭ－ １、ＩＦＮγ和ＩｇＥ水平。结果　在支气管哮喘发作期血清ＩＬ－４、ｓＩＣＡＭ－１、ＩｇＥ水平明显升高，ＩＦＮγ水平明显降低；在缓解期和经强的松治疗后，血清ＩＬ－４、ｓＩＣＡＭ－ １、ＩｇＥ水平明显降低。结论　ＩＬ－４ 可促进ｓＩＣＡＭ－１ 表达及ＩｇＥ分泌，并可抑制ＩＦＮγ的分泌，因此在支气管哮喘发病中起重要作用。Objective To explore the relationship between IL-4,soluble sICAM-1,IFNγ and IgE in allergic bronchial asthma .Methods The levels of IL-4,sICAM-1,IFNγ and IgE in the serum were measured by enzyme linked immunosorbent assay(ELISA) in 54 cases of allergic bronchial asthma and 51 controls.Results Significant elevation and reduction of IL-4,sICAM-1,and IgE in serum of attack and remission stage of patients with allergic bronchial asthma as compared with that in controls were observed respectively(P<0 05).In contrast,the levels of IFNγ were obviously lower in serum of patients with allergic bronchial asthma groups than in control groups(P<0 05).There were a positive correlation between IL-4,sICAM-1 and IgE(r=0 83,r=0 61) and a negative correlation between IFNγ and IgE(r=-0 53).Conclusion Data suggests that IL-4,sIACM-1 and IFNγ were important regulative factors in IgE production.

关 键 词：哮喘 IGE IL-4 SICAM-1 IFNΓ 

分 类 号：R562.250.2[医药卫生—呼吸系统]