Mohnarin 2009年度报告:西北地区细菌耐药监测  

Mohnarin 2009 annual report:Bacterial drug resistant surveillance in northwest of China

作　　者：徐修礼[1] 杨佩红[1] 樊新[1] 孙怡群[1] 刘家云[1] 周珊[1] 郝晓柯[1] 

机构地区：[1]第四军医大学西京医院全军临床检验医学中心,西安710032

出　　处：《中国临床药理学杂志》2011年第7期517-523,共7页The Chinese Journal of Clinical Pharmacology

摘　　要：目的总结西北地区十一家教学医院2009年度临床分离病原菌的耐药状况。方法常规方法培养分离医院内感染病原菌,并用半自动或全自动细菌鉴定分析仪鉴定到种;药敏试验方法按CLSI规定的标准进行;监测数据按卫生部全国细菌耐药监测(Mohnarin)中心设计方案的要求定期上报;用WHONET5.5软件进行数据统计分析。结果西北地区11家教学医院共分离出病原菌株19404株,其中革兰阴性菌14170株,占分离菌的73.03%;革兰阳性菌5234株,占分离菌的26.97%。大肠埃希菌和肺炎克雷伯菌超广谱β内酰胺酶的产生率分别为65.7%和42.9%。铜绿假单胞菌和鲍曼不动杆菌对多粘菌素的敏感率为97%左右。耐甲氧西林的金黄色葡萄球菌(MRSA)与凝固酶阴性葡萄球菌(MRSCoN)的发生率分别为61.4%和84.9%;未发现对万古霉素和利奈唑胺耐药的葡萄球菌。表皮葡萄球菌、溶血葡萄球菌对替考拉宁的耐药率分别为1.8%和1.2%。粪肠球菌对替考拉宁和万古霉素耐药率分别为0.9%,1.2%;屎肠球菌对替考拉宁和万古霉素耐药率分别为1.6%,2.3%。结论细菌的耐药性有逐年上升的趋势,而且耐药现象存在地区差异。MRS、产ESBL酶的肠杆菌、多药耐药的铜绿假单胞菌、泛耐药的鲍曼不动杆菌仍然是耐药监测值得关注的病原菌。Objective To summarize 2009 annual clinical isolated-drug resistance in Northwest of China with eleven teaching hospitals.Methods Isolates were cultured by routine method and identified by the semi-automatic or automatic bacteria analysis system.Drug susceptibility test was according to CLSI standards.Supervising data delivered to MOH National Antimicrobial Resistant Investigation Net（Mohnarin） according to its plan.Data statistic and analysis used WHONET5.5 soft ware.Results Nighteen thousanol four hundred and four strains pathogens were isolated in Northwest area with eleven teaching hospital,in which gram negative bacteria had 14407 strains（73.03%）,gram positive bacteria had 5234 strains（26.97%）.The positive ratio of producing ESBLs-E.coli was 65.7%,ESBLs-Klebsiella spp was 42.9%.The drug susceptible rate of Pseudomonas aeruginosa and Acinetobacter baumannii against polymyxin were 97%.MRSA were 60.98%,MRSE were 77.15%.Resistant vancomycin and linezolid to Staphylococcus didn＇t detect.The drug resistant rate of Staphylococcus epicermidis against teicoplanin was 1.8% and Staphylococcu heamolyticus was 1.2%.The drug resistant rates of Enterococcus faecalis against teicoplanin and vancomycin were 0.9% and 1.2%.Enterococcus faecium were 1.6% and 2.3%.Conclusion The bacterial resistance is still on the rise.And the drugs resistance has regional differences.Much attention should be paid to MRS,ESBLs-Enterobacteriaceae,multi-drug resistance Pseudomonas aeruginosa and pan-drug resistance Acinetobacter baumannii.

关 键 词：细菌 抗菌药物 耐药监测 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]