肺挫伤患者血清可溶性白细胞分化抗原14、可溶性E选择素、肿瘤坏死因子α水平的变化及意义  

Serum Levels of Soluble CD14,Soluble E-Selectin and Tumour Necrosis Factor Alpha in Patients with Pulmonary Contusion

作　　者：刘辉[1] 岳峰涛[1] 向明[1] 刘俊钧[1] 

机构地区：[1]复旦大学附属上海市第五人民医院胸外科,上海200240

出　　处：《中国临床医学》2011年第3期335-337,共3页Chinese Journal of Clinical Medicine

基　　金：上海市闵行区科委资助项目(编号:2008MH-046)

摘　　要：目的:观察肺挫伤患者血清可溶性白细胞分化抗原14(soluble CD14,sCD14)、可溶性E选择素(soluble E-selectin,sE-selectin)、肿瘤坏死因子α(tumor necrosis factor-alpha,TNF-α)水平的动态变化及其与伤后肺损伤发展的关系。方法:用酶联免疫吸附试验(ELISA)法检测35例肺挫伤患者伤后6h、12h、1d、3d、5d、7d血清sCD14、sE-selectin、TNF-α含量及30例健康成人血清中以上3种因子的含量,比较血清中sCD14、sE-selectin、TNF-α含量在肺挫伤患者和健康成人中的差异以及sCD14、sE-selectin、TNF-α与伤后急性肺损伤(ALI)和急性呼吸窘迫综合征(ARDS)的关系。结果:肺挫伤患者伤后6h血清sCD14、sE-selectin、TNF-α含量即显著升高,且sCD14s、E-selectin含量与ALI和ARDS的发生关系密切,伤后血清sCD14、sE-selectin、TNF-α含量呈显著正相关。结论:血清sCD14、sE-selectin、TNF-α与肺挫伤的发生发展关系密切。Objective：To study the serum levels of soluble CD14（sCD14）,soluble E-selectin（sE-selectin）,tumour necrosis factor alpha（TNF-α） in pulmonary contusion and the relationships between those molecules and subsequent lung injury.Methods：Serum levels of sCD14,sE-selectin,TNF-α were dynamically observed by enzyme linked immunoabsorbed assay（ELISA） in 35 patients with pulmonary contusion 6 h,12 h and 1 d,3 d,5 d,7 d after trauma and in 30 healthy persons from March 2008 to April 2010.Results：Six hours after trauma,sCD14,sE-selectin and TNF-α could be noticed have a significant increase compared with healthy ones.Patients with acute lung injury（ALI） or acute respiratory distress syndrome（ARDS） showed higher sCD14 and sE-selectin concentrations than other patients.sCD14,sE-selectin and TNF-α had significantly positive correlation with each other.Conclusions：sCD14,sE-selectin and TNF-α may play important roles in development and progression of pulmonary contusion.

关 键 词：肺挫伤 可溶性白细胞分化抗原14 可溶性E选择素 肿瘤坏死因子Α 

分 类 号：R655.3[医药卫生—外科学]