甘精胰岛素对老年2型糖尿病患者β细胞功能的影响  

The Effects of Insulin Glargine in Elderly Patients with Newly Diagnosed Type 2 Diabetes on β-Cell Function

作　　者：毕明慧[1] 

机构地区：[1]上海市徐汇区中心医院老年病科,上海200031

出　　处：《中国临床医学》2011年第3期367-368,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨甘精胰岛素对于老年新诊断2型糖尿病患者的β细胞功能影响。方法:50例老年新诊断2型糖尿病患者随机分为2组:甘精胰岛素治疗组(G组)和门冬胰岛素30治疗组(N组),进行为期2周的治疗,计算治疗前后患者的胰岛β细胞功能指数。结果:2组患者的胰岛功能均有一定程度的改善,与治疗前相比存在显著差异(P<0.001)。但是治疗后,N组患者的糖负荷30min后胰岛素增量与葡萄糖增量的比值(ΔI30/ΔG30)较G组患者改善更为明显(P<0.05)。结论:对于老年新诊断的2型糖尿病患者,早期用甘精胰岛素治疗有利于改善其胰岛β细胞功能。Objective：To investigate the effects of insulin glargine in elderly patients with newly diagnosed type 2 diabetes on β-cell function.Methods：A total of 50 patients with newly diagnosed type 2 diabetics were randomly divided into two groups,the glargine treatment group（Group G） and aspart 30 treatment group（Group N）.All patients were received treatment for 2 weeks.The islet β cell function index were calculated before and after the treatment.Results：Islet function in both groups had some degree of improvement,compared with before treatment were significantly different（P0.001）.However after treatment,the delta I30/delta G30 ratio（ΔI30/ΔG30） in Group N were obviously improved more than in Group G（P0.05）.Conclusions：For the newly diagnosed elderly patients with type 2 diabetes,early using of insulin glargine will help to improve the islet β-cell function.

关 键 词：2型糖尿病 胰岛功能 甘精胰岛素 

分 类 号：Q977.15[生物学]