微波辐射下离子液体介质中经由Passerini反应合成α-酰氧基酰胺及α-酰氧基酰胺-嘧啶核苷杂化体  

Preparation of Acyloxycarboxamides and Their Hybrids with Pyrimidine Nucleoside through Microwave Irradiated Passerini Reaction in Ionic Liquid

作　　者：王国利[1] 薛载坤[1] 王洋洋[1] 尹雪娜[1] 张春[1] 潘卉妍[1] 范学森[1] 

机构地区：[1]河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡453007

出　　处：《化学通报》2011年第7期639-645,共7页Chemistry

基　　金：国家自然科学基金项目(20972042);河南省自然科学基金项目(092300410237);国家大学生创新性实验计划项目(091047620)资助

摘　　要：研究了微波辐射下离子液体介质中的羧酸、醛及异腈的三组分反应,即Passerini反应。研究发现,该反应可在微波辐射条件下很快完成,并以较高的收率生成相应的α-酰氧基酰胺类衍生物。与文献方法相比,该方法具有对环境友好、效率高、操作简便、反应条件温和等优点。笔者已经成功地将这一方法应用到了具有潜在生物活性的α-酰氧基酰胺-嘧啶核苷杂化体的合成中。Three-component reaction of carboxylic acid,aldehyde and isocyanide,known as the Passerini reaction,was carried out efficiently in PF6 under microwave irradiation.Through this reaction,a series of acyloxycarboxamides were obtained.This novel procedure showed such advantages as environmentally benign,enhanced efficiency,simple operation and mild reaction conditions.As an extension,the procedure was successfully applied in the preparation of pyrimidine nucleoside-acyloxycarboxamide hybrids which possess potential biological activities.

关 键 词：α-酰氧基酰胺 Passerini反应 嘧啶核苷 微波照射 多组分反应 离子液体 

分 类 号：O621.3[理学—有机化学]