重庆市男男性行为者HIV抗体阳转率及其影响因素研究  

Study on HIV-1 seroconversion rate and its associated factors among men who have sex with men in Chongqing City

作　　者：冯连贵[1] 丁贤彬[2] 卢戎戎[2] 欧阳琳[2] 郑建琼[2] 徐静[2] 韩梅[3] 郭晓嘉[2] 杨明芳[2] 徐世明[2] 

机构地区：[1]重庆市疾病预防控制中心,重庆400042 [2]重庆市疾病预防控制中心性艾所,重庆400042 [3]重庆市疾病预防控制中心微生物安全检测所,重庆400042

出　　处：《中华疾病控制杂志》2011年第7期564-567,共4页Chinese Journal of Disease Control & Prevention

基　　金：卫生部2007年艾滋病防治应用性研究项目(WA-2007-03)

摘　　要：目的了解男男性行为者(men who have sex with men,MSM)人群HIV抗体阳转率及其影响因素,为评估MSM人群艾滋病防治效果与开展针对性防治工作提供依据。方法对招募自愿参加随访研究的HIV与梅毒均阴性的MSM进行随访,6个月后再次进行问卷调查与采集血样检测HIV与梅毒,以HIV抗体阳转率为应变量,人口学特征、性行为情况等为自变量进行Logistic回归,分析鉴别HIV抗体阳转率的影响因素。结果 214例MSM参加随访,平均年龄(25.6±6.3)岁,88.3%的人最近6个月与男性有肛交史,最近6个月平均性伴数为2个,最近一次与男性发生肛交时安全套使用率为76.2%,最近6个月发生保护性肛交的比例为52.4%。HIV抗体阳转率及95%CI为12.5(9.1～15.7)/100人年,梅毒的发病率及95%CI为17.8(13.1～23.5)/100人年。多因素回归分析显示,文化程度(OR=0.27,95%CI:0.13～0.59)、梅毒感染(OR=9.23,95%CI:2.42～35.18)是HIV抗体阳转率的独立影响因素。结论重庆市MSM人群HIV抗体阳转率高,安全套使用率低,防治形势严峻。Objective To understand HIV seroconversion rate and its associated factors among men who have sex with men, so as to provide the evidence for evaluating the effect and developing the comprehensive strategy for AIDS pre- vention and control among men who have sex with men. Methods MSM with HIV and Syphilis negative recruited were interviewed with the structured questionnaire and blood sample test for HIV and Syphilis antibody were taken after six months. HIV seroconversion rate and its influencing factors were analyzed by multivariate Logistic regression. Results A total of 214 MSM participated in the follow-up study. The average age was 25.6 ± 6.3. 88.3% of them had anal sex with men. The number of partners was 2 （median）. The rate of condom use in the last time and in recent six months was 76.2 % and 52.4 % respectively. HIV seroconversion rate was 12.5 （9.1 - 15.7）/100 person-year. Syphilis incidence was 17.8（ 13.1-23.5）/100 person-year. The result of multivariate analysis indicated that education level （OR = 0.27, 95% CI：0. 13--0.59） and Syphilis positive （OR = 9.23,95% CI ：2. 42- 35.18 ） were independent factors of HIV seroconversion rate. Conclusions HIV seroconversion rate is high and the rate of condom use is low among men who have sex with men. AIDS epidemic among men who have sex with men is serious.

关 键 词：同性恋 男性 HIV 随访研究 

分 类 号：R181.1[医药卫生—流行病学] R512.91[医药卫生—公共卫生与预防医学]