盐酸舍曲林片在稳定期慢性阻塞性肺疾病合并抑郁症的临床应用  

Clinical application of sertraline hydrochloride tablets in patients with stable chronic obstructive pulmonary disease accompanied with depression

作　　者：何远强[1] 郑玉龙[1] 徐跃[1] 周黎阳[1] 刘淑[1] 张兵[1] 

机构地区：[1]淮安市第二人民医院呼吸科,江苏淮安223002

出　　处：《中国医院药学杂志》2011年第14期1210-1212,共3页Chinese Journal of Hospital Pharmacy

基　　金：江苏省淮安市S科技支撑计划(社会发展)(编号:HAS2009001-3)

摘　　要：目的:探讨盐酸舍曲林片对抑郁的稳定期慢性阻塞性肺疾病患者的影响。方法:将120例抑郁的稳定期慢性阻塞性肺疾病患者随机分为常规组和实验组,常规组仅实施常规的治疗,实验组除给予常规的治疗,还给予盐酸舍曲林片口服,抗抑郁治疗,5周后评价患者的肺功能及抑郁状态。结果:实验组和常规组比较,患者肺功能指标改善,HAMD评分亦显著低于常规组(P<0.05)。结论:盐酸舍曲林片能改善慢性阻塞性肺疾病患者的肺功能及抑郁情绪。OBJECTIVE To investigate the influence of sertraline hydrochloride tablets in patients with chronic obstructive pulmonary disease accompanied with depression. METHODS 120 patients with chronic obstructive pulmonary disease accompa nied with depression were randomly divided into conventional group and experimental group, the conventional group was only given conventional treatments, while the experimental experimental group was given sertraline hydrochloride tablets addilional- ly. The pulmonary function and depression were evaluated in patients after 5 weeks. RESULTS Comparing with tile conven tional group, the pulmonary function of experimental group was improved significantly, HAMD scores were also significantly lower than the conventional group（P〈0. 05）. CONCLUSION Sertraline hydrochloride tablets can improve pulmonary function and depression in patients with chronic obstructive pulmonary disease.

关 键 词：慢性阻塞性肺疾病 抑郁 盐酸舍曲林片 

分 类 号：R969.4[医药卫生—药理学]