可溶性sHLA-G在子痫前期患者与正常晚孕妇女血中的表达  

Study on the comparative of soluble sHLA-G expression between preeclampsia and late pregnant women

作　　者：胡进霞[1] 黎玉红[1] 刘丽[1] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001

出　　处：《宁夏医学杂志》2011年第7期593-594,共2页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ09170)

摘　　要：目的探讨可溶性白细胞抗原G(sHLA-G)在子痫前期发病中的意义。方法采用酶联免疫吸附法(ELISA)测定45例子痫前期患者,49例正常足月妊娠者外周静脉血及靠近胎盘部位处脐静脉血中可溶性(sHLA-G)水平。结果子痫前期组外周血sHLA-G浓度为(6.61±2.51)μg/L,正常组外周血sHLA-G浓度(22.03±3.12)μg/L,两组比较差异有统计学意义(P<0.05);子痫前期组脐静脉血sHLA-G浓度为(7.23±2.12)μg/L,正常组脐静脉血sHLA-G浓度(25.21±3.70)μg/L,差异有统计学意义(P<0.05);子痫前期组外周血sHLA-G浓度为(6.61±2.51)μg/L,脐静脉血sHLA-G浓度为(7.23±2.12)μg/L,差异无统计学意义(P>0.05);正常组外周血sHLA-G浓度(22.03±3.12)μg/L,脐静脉血sHLA-G浓度(25.21±3.70)μg/L,两组比较差异有统计学意义(P<0.05)。结论妊娠妇女血中sHLA-G水平的下降可能导致子痫前期的发病,血中sHLA-G主要来源于胎盘组织。Objective To detected the expression of human leukocyte antigen-G（sHLA-G） in maternal serum and placenta in pregnant with preeclampsia,and to discus sHLA-G in the pathogenesis of preeclampsia.Methods The level of placenta sHLA-G was measured by ELISA in 45 patients with preeclampsia and 49 normal pregnant cases.Results There was significant difference in level of sHLA-G of blood（6.61±2.51;22.03±3.12） between preeclampsia and normal pregnant cases（P〈0.05）;there was significant difference in sHLA-G of cord blood（7.23±2.12;25.21±3.70） between preeclampsia and normal pregnant cases（P〈0.05）;There was no significant difference between the blood and cord blood of level of sHLA-G in preeclampsia（6.61±2.51;7.23±2.12）（P〉0.05）;There was significant difference in level of sHLA-G of normal pregnant cases（22.03±3.12;25.21±3.70） between the blood and cord blood of（P〈0.05）.Conclusion Decrease of sHLA-G level in pregnant women may lead to the incidence of preeclampsia.

关 键 词：子痫前期 可溶性白细胞抗原-G(sHLA—G) 血清 

分 类 号：R714.245[医药卫生—妇产科学]