柴油车尾气颗粒物对小鼠胚胎发育不良影响的初步研究  

Preliminary study of adverse effects of diesel exhaust particles on mice embryonic development

作　　者：叶雯婧[1] 郑铃[1] 李旭冰[1] 王章敬[1] 杨芬 

机构地区：[1]福建医科大学公共卫生学院流行病与卫生统计学系,福州350004 [2]三明职业技术学院妇产科,福建365000

出　　处：《海峡预防医学杂志》2011年第3期10-12,94,共4页Strait Journal of Preventive Medicine

基　　金：福建省科技厅计划重点项目基金(No.2007Y0017)

摘　　要：目的初步探讨柴油车尾气颗粒对胚胎发育的不良影响。方法从孕鼠妊娠起经腹腔注射从某交通繁华路段收集的柴油车尾气颗粒,按高剂量7.4mg/(kg.d)、低剂量组(4.4/(kg.d)和二甲亚砜对照组进行研究。结果高剂量组非存活胎鼠发生率(23.8%)和活胎鼠宫内发育迟缓发生率(9.8%)均高于对照组;高低剂量组均出现外观畸形的活胎鼠,对照组的活胎鼠外观正常。2个实验组均发生不同程度的组织病理损伤,主要表现为不同程度的滋养层细胞增生、合体细胞结节形成,以及充血和炎性细胞侵润。结论柴油车尾气颗粒物可造成胎盘不同程度的组织病理损伤,增加了宫内发育迟缓和外观畸形的发生率。Objective To explore the effects of diesel exhaust particles on mice embryonic development.Methods Pregnant mice were injected intraperitoneally with diesel exhaust particles collected in a busy traffic section at doses of 7.4 mg/（kg·d）（high dose group） and 4.4 mg/（kg·d）（low dose group） and dimethylsulfoxide to the control group.Results The rate of non-viable fetuses（23.8%） and intrauterine growth retardation（IUGR）（9.8%）of live fetal,and they were significantly higher than that in the control group.Live fetal showed external appearance malformation in experiment groups,and normal appearance in the control group.There were pathological injuries in varying degree in two experiment groups.Conclusions Diesel exhaust particles can result in pathological damage to experimental mice to a certain degree,and the rate increasing of intrauterine growth retardation and malformations.

关 键 词：柴油车尾气颗粒物 小鼠胚胎 胎盘 病理组织学 环境毒理学 

分 类 号：R994.6[医药卫生—毒理学] R-332[医药卫生—药学]