游离皮瓣移植术后帕瑞昔布钠联合芬太尼镇痛疗效分析  

Analgesic Effect of Parecoxib Soduim Combined With Fentanyl in Patients Undergoing the Surgery of Free Skin Flap

作　　者：王白云[1] 梁娜[1] 罗红菱[1] 王永东 

机构地区：[1]南华大学附属南华医院麻醉科,湖南衡阳421002

出　　处：《中南医学科学杂志》2011年第3期283-285,共3页Medical Science Journal of Central South China

摘　　要：目的观察帕瑞昔布钠联合芬太尼在游离皮瓣移植术后的镇痛效果。方法选择ASAI～Ⅱ级需行游离皮瓣移植术病例40例，随机分成联合组（帕瑞昔布钠联合芬太尼）和芬太尼组各20例。于手术结束前30min，联合组静注帕瑞昔布钠40mg，芬太尼组静注生理盐水4mL。术后均采用芬太尼自控静脉镇痛（PCIA）。记录术后2、4、12和24h两组VAS评分、术后24h两组PCA按压总次数和有效次数、芬太尼的用量及不良反应。结果联合组术后2、4、12和24h两组VAS评分、术后24h两组PCA按压总次数和有效次数、芬太尼的用量均明显少于芬太尼组（P〈0．05）。两组不良反应的差异无统计学意义。结论帕瑞昔布钠联合芬太尼用于游离皮瓣移植术后PCIA镇痛效果更好。能减少术后芬太尼的用量。Objective To investigate the analgesic effect of parecoxib soduim combined with fentanyl in patients undergoing the surgery of free skin flap. Methods 40 cases undergoing the surgery of free skin flap were randomly divided into P group or F group ,20 cases in each group. Group P received intravenous parecoxib soduim 40 nag and group F received intravenous NS 4 mL 30 minutes before the end of the operation. PCIA with fentanyl was used for postoperative analgesia in all patients. VAS was recorded at 2,4,12, and 24 h after operation. The total number and the valid number of pressing PCA pump, the total consumption of fentanyl and adverse effects were recorded at 24 h after operation. Results Compared with group F, there were significant decreases in the score of VAS, fentanyl consumption, the total number and the valid number of pressing PCA pump in group P（ P 〈 0.05 ）at different time points after operation. Adverse effects had no significant difference between the two groups. Conclusions Intravenenous analgesia of pareeoxib soduim combined with fentanyl offers better analgesic effect and is able to reduce fentanyl consumption in patients undergoing the surgery of free skin flap.

关 键 词：帕瑞昔布钠 芬太尼 术后镇痛 游离皮瓣 

分 类 号：R614[医药卫生—麻醉学]